(S)-7-(5-methyl-2,3-diphenyl-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)heptanoic acid

Base Information

Chemical Name:(S)-7-(5-methyl-2,3-diphenyl-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)heptanoic acid
CAS No.:1447768-40-2
Molecular Formula:C₂₇H₃₁N₃O₂
Molecular Weight:429.562
Hs Code.:

Synonyms:(S)-7-(5-methyl-2,3-diphenyl-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)heptanoic acid

Suppliers and Price of (S)-7-(5-methyl-2,3-diphenyl-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)heptanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-7-(5-methyl-2,3-diphenyl-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)heptanoic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-7-(5-methyl-2,3-diphenyl-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)heptanoic acid

There total 5 articles about (S)-7-(5-methyl-2,3-diphenyl-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1447768-39-9
7-(5-methyl-2,3-diphenyl-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)heptanoic acid

: 1447768-40-2
(S)-7-(5-methyl-2,3-diphenyl-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)heptanoic acid

: 1447768-41-3
(R)-7-(5-methyl-2,3-diphenyl-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)heptanoic acid

Guidance literature:: With Chiralpak AD-H column; In carbon dioxide; isopropyl alcohol; Resolution of racemate; liquid CO₂;

Reference yield:

: 1447768-74-2
rac-ethyl 7-(5-methyl-2,3-diphenyl-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)heptanoate

: 1447768-40-2
(S)-7-(5-methyl-2,3-diphenyl-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)heptanoic acid

: 1447768-41-3
(R)-7-(5-methyl-2,3-diphenyl-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)heptanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide; water / tetrahydrofuran / 18 h / 20 °C

2: Chiralpak AD-H column / isopropyl alcohol; carbon dioxide / Resolution of racemate; liquid CO₂

With water; lithium hydroxide; In tetrahydrofuran; carbon dioxide; isopropyl alcohol;

Reference yield:

: 67899-59-6
2,3-diphenylpyrido<3,4-b>pyrazine

: 1447768-40-2
(S)-7-(5-methyl-2,3-diphenyl-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)heptanoic acid

: 1447768-41-3
(R)-7-(5-methyl-2,3-diphenyl-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)heptanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 0.17 h / -25 - -20 °C

1.2: 1.5 h / -20 - 0 °C

2.1: ammonium formate; palladium 10% on activated carbon / water; methanol / 1 h / Reflux

3.1: tetrahydrofuran / 2 h / -30 - 20 °C

4.1: triethylamine / 1,2-dichloro-ethane / 0.25 h / 20 °C

4.2: 18 h / 60 °C

5.1: lithium hydroxide; water / tetrahydrofuran / 18 h / 20 °C

6.1: Chiralpak AD-H column / isopropyl alcohol; carbon dioxide / Resolution of racemate; liquid CO₂

With palladium 10% on activated carbon; water; ammonium formate; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; carbon dioxide; water; 1,2-dichloro-ethane; isopropyl alcohol;