(1S,6S)-3,3-dimethyl-5,5-diphenyl-2,4-dioxa-7-aza-3-silabicyclo[4.2.1]nonane

Base Information

Chemical Name:(1S,6S)-3,3-dimethyl-5,5-diphenyl-2,4-dioxa-7-aza-3-silabicyclo[4.2.1]nonane
CAS No.:1434302-17-6
Molecular Formula:C₁₉H₂₃NO₂Si
Molecular Weight:325.483
Hs Code.:

Synonyms:(1S,6S)-3,3-dimethyl-5,5-diphenyl-2,4-dioxa-7-aza-3-silabicyclo[4.2.1]nonane

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Chemical Property of (1S,6S)-3,3-dimethyl-5,5-diphenyl-2,4-dioxa-7-aza-3-silabicyclo[4.2.1]nonane

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Technology Process of (1S,6S)-3,3-dimethyl-5,5-diphenyl-2,4-dioxa-7-aza-3-silabicyclo[4.2.1]nonane

There total 2 articles about (1S,6S)-3,3-dimethyl-5,5-diphenyl-2,4-dioxa-7-aza-3-silabicyclo[4.2.1]nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1434302-13-2
(1S,6S)-benzyl 3,3-dimethyl-5,5-diphenyl-2,4-dioxa-7-aza-3-silabicyclo[4.2.1]nonane-7-carboxylate

: 1434302-17-6
(1S,6S)-3,3-dimethyl-5,5-diphenyl-2,4-dioxa-7-aza-3-silabicyclo[4.2.1]nonane

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; at 20 ℃; for 36h;
DOI:10.1002/adsc.201200922

Reference yield:

: 13504-85-3
(2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid

: 1434302-17-6
(1S,6S)-3,3-dimethyl-5,5-diphenyl-2,4-dioxa-7-aza-3-silabicyclo[4.2.1]nonane

Guidance literature:: Multi-step reaction with 4 steps

1: diethylazodicarboxylate; triphenylphosphine / toluene; tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere

2: tetrahydrofuran; diethyl ether / 8.5 h / 0 - 20 °C / Inert atmosphere

3: 1H-imidazole / N,N-dimethyl-formamide / 19 h / 0 - 20 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 36 h / 20 °C

With 1H-imidazole; palladium 10% on activated carbon; hydrogen; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide; toluene;
DOI:10.1002/adsc.201200922