dimethyl (2R,4S)-2-{[bis(4-bromobenzyloxy)phosphoryl]methyl}-4-{[tert-butyl(dimethyl)silyl]oxy}pentanedioate

Base Information

Chemical Name:dimethyl (2R,4S)-2-{[bis(4-bromobenzyloxy)phosphoryl]methyl}-4-{[tert-butyl(dimethyl)silyl]oxy}pentanedioate
CAS No.:1312438-96-2
Molecular Formula:C₂₈H₃₉Br₂O₈PSi
Molecular Weight:722.48
Hs Code.:

Synonyms:dimethyl (2R,4S)-2-{[bis(4-bromobenzyloxy)phosphoryl]methyl}-4-{[tert-butyl(dimethyl)silyl]oxy}pentanedioate

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Chemical Property of dimethyl (2R,4S)-2-{[bis(4-bromobenzyloxy)phosphoryl]methyl}-4-{[tert-butyl(dimethyl)silyl]oxy}pentanedioate

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Technology Process of dimethyl (2R,4S)-2-{[bis(4-bromobenzyloxy)phosphoryl]methyl}-4-{[tert-butyl(dimethyl)silyl]oxy}pentanedioate

There total 3 articles about dimethyl (2R,4S)-2-{[bis(4-bromobenzyloxy)phosphoryl]methyl}-4-{[tert-butyl(dimethyl)silyl]oxy}pentanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312438-92-8
2-fluoro-4-methylenepentanedioic acid dimethyl ester

: 1312438-97-3
dimethyl (2S,4S)-2-{[bis(4-bromobenzyloxy)phosphoryl]methyl}-4-{[tert-butyl(dimethyl)silyl]oxy}pentanedioate

: 1312438-96-2
dimethyl (2R,4S)-2-{[bis(4-bromobenzyloxy)phosphoryl]methyl}-4-{[tert-butyl(dimethyl)silyl]oxy}pentanedioate

Guidance literature:: With Chiralpak IC; In ethanol; hexane; at 20 ℃; Resolution of racemate;

Reference yield:

: 4224-69-5
methyl 2-(bromomethyl)propenoate

: 1312438-96-2
dimethyl (2R,4S)-2-{[bis(4-bromobenzyloxy)phosphoryl]methyl}-4-{[tert-butyl(dimethyl)silyl]oxy}pentanedioate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; indium / water; methanol / 4 h / 5 - 35 °C

2: Nonafluorobutanesulfonyl fluoride; triethylamine; triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 20 h / 20 °C

3: Chiralpak IC / hexane; ethanol / 20 °C / Resolution of racemate

With hydrogenchloride; indium; Nonafluorobutanesulfonyl fluoride; triethylamine tris(hydrogen fluoride); triethylamine; In tetrahydrofuran; methanol; ethanol; hexane; water;

Reference yield:

: 1312438-70-2
dimethyl 2-hydroxy-4-methylenepentanedioate

: 1312438-96-2
dimethyl (2R,4S)-2-{[bis(4-bromobenzyloxy)phosphoryl]methyl}-4-{[tert-butyl(dimethyl)silyl]oxy}pentanedioate

Guidance literature:: Multi-step reaction with 2 steps

1: Nonafluorobutanesulfonyl fluoride; triethylamine; triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 20 h / 20 °C

2: Chiralpak IC / hexane; ethanol / 20 °C / Resolution of racemate

With Nonafluorobutanesulfonyl fluoride; triethylamine tris(hydrogen fluoride); triethylamine; In tetrahydrofuran; ethanol; hexane;