1-(6-hydroxynaphthalen-2-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol

Base Information

• Chemical Name: 1-(6-hydroxynaphthalen-2-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol
• CAS No.: 247173-85-9
• Molecular Formula: C₃₆H₃₂N₂O₂
• Molecular Weight: 524.662
• Mol file: 247173-85-9.mol

Synonyms:1-(6-hydroxynaphthalen-2-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol

Chemical Property of 1-(6-hydroxynaphthalen-2-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(6-hydroxynaphthalen-2-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol

There total 4 articles about 1-(6-hydroxynaphthalen-2-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(6-Benzyloxynaphthalen-2-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol (247173-83-7) → 1-(6-hydroxynaphthalen-2-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol (247173-85-9)

Guidance literature:

palladium-carbon; In tetrahydrofuran; methanol;

Reference yield:

6-bromo-naphthalen-2-ol (15231-91-1) → 1-(6-hydroxynaphthalen-2-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol (247173-85-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

1.2: 0 °C

2.1: n-butyllithium / tetrahydrofuran / 0.33 h / -70 °C

2.2: 0.83 h / -70 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C

With 1H-imidazole; n-butyllithium; tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2011.01.017

Reference yield:

(6-bromonaphthalen-2-yloxy)-tert-butyldimethylsilane (100751-65-3) → 1-(6-hydroxynaphthalen-2-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol (247173-85-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 0.33 h / -70 °C

1.2: 0.83 h / -70 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C

With n-butyllithium; tetrabutyl ammonium fluoride; In tetrahydrofuran;

DOI:10.1016/j.bmc.2011.01.017

upstream raw materials:

1-(6-Benzyloxynaphthalen-2-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol

6-bromo-naphthalen-2-ol

(6-bromonaphthalen-2-yloxy)-tert-butyldimethylsilane

Downstream raw materials:

6-[1-Hydroxy-1-(1-trityl-1H-imidazol-4-yl)-2-methylpropyl]naphthalen-2-yloxymethyl 2,2-Dimethylpropionate

1-(6-Acetoxynaphthalen-2-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol

6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthyl trifluoromethanesulfonate

6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-N-isopropyl-2-naphthamide