4-{[6-amino-2-(2-methoxyethoxy)-8-oxo-7H-purine-9(8H)-yl]methyl}benzoic acid

Base Information

• Chemical Name: 4-{[6-amino-2-(2-methoxyethoxy)-8-oxo-7H-purine-9(8H)-yl]methyl}benzoic acid
• CAS No.: 1062444-54-5
• Molecular Formula: C₁₆H₁₇N₅O₅
• Molecular Weight: 359.341
• Mol file: 1062444-54-5.mol

Synonyms:4-{[6-amino-2-(2-methoxyethoxy)-8-oxo-7H-purine-9(8H)-yl]methyl}benzoic acid

Chemical Property of 4-{[6-amino-2-(2-methoxyethoxy)-8-oxo-7H-purine-9(8H)-yl]methyl}benzoic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

1V209(TLR7agonistT7) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-{[6-amino-2-(2-methoxyethoxy)-8-oxo-7H-purine-9(8H)-yl]methyl}benzoic acid

There total 7 articles about 4-{[6-amino-2-(2-methoxyethoxy)-8-oxo-7H-purine-9(8H)-yl]methyl}benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-((6-amino-8-methoxy-2-(2-methoxyethoxy)-9H-purin-9-yl)methyl)benzonitrile (927822-43-3) → 4-{[6-amino-2-(2-methoxyethoxy)-8-oxo-7H-purine-9(8H)-yl]methyl}benzoic acid (1062444-54-5)

Guidance literature:

4-((6-amino-8-methoxy-2-(2-methoxyethoxy)-9H-purin-9-yl)methyl)benzonitrile; With water; sodium hydroxide; In ethanol; for 8h; Reflux;

With hydrogenchloride; In ethanol; water; pH=2;

Reference yield:

methyl 4-[6-amino-8-methoxy-2-(2-methoxyethoxy)purin-9-ylmethyl]benzoate (927822-46-6) → 2-methoxyethoxy-8-oxo-9-(4-carboxybenzyl)adenine (1062444-54-5)

Guidance literature:

With chloro-trimethyl-silane; sodium iodide; In acetonitrile; at 70 ℃; for 6h;

Reference yield:

C17H19N5O5 → 4-{[6-amino-2-(2-methoxyethoxy)-8-oxo-7H-purine-9(8H)-yl]methyl}benzoic acid (1062444-54-5)

Guidance literature:

With chloro-trimethyl-silane; sodium iodide; In acetonitrile; at 50 ℃; for 3h;

upstream raw materials:

methyl 4-[6-amino-8-methoxy-2-(2-methoxyethoxy)purin-9-ylmethyl]benzoate

4-((6-amino-8-methoxy-2-(2-methoxyethoxy)-9H-purin-9-yl)methyl)benzonitrile