4-(fluoromethyl)-N-(2-(4-(2-hydroxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)cubane-1-carboxamide

Base Information

Chemical Name:4-(fluoromethyl)-N-(2-(4-(2-hydroxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)cubane-1-carboxamide
CAS No.:1350821-91-8
Molecular Formula:C₂₇H₂₉FN₄O₂
Molecular Weight:460.551
Hs Code.:

Synonyms:4-(fluoromethyl)-N-(2-(4-(2-hydroxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)cubane-1-carboxamide

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Chemical Property of 4-(fluoromethyl)-N-(2-(4-(2-hydroxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)cubane-1-carboxamide

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Technology Process of 4-(fluoromethyl)-N-(2-(4-(2-hydroxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)cubane-1-carboxamide

There total 7 articles about 4-(fluoromethyl)-N-(2-(4-(2-hydroxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)cubane-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₇H₃₆F₂N₄O₃

: 1350821-91-8
4-(fluoromethyl)-N-(2-(4-(2-hydroxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)cubane-1-carboxamide

Guidance literature:: With water; sodium hydrogencarbonate; In methanol; at 50 ℃; for 2h;
DOI:10.1016/j.ejmech.2011.06.023

Reference yield:

: 1350821-99-6
methyl 4-(bromomethyl)cubane-1-carboxylate

: 1350821-91-8
4-(fluoromethyl)-N-(2-(4-(2-hydroxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)cubane-1-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: tetrabutyl ammonium fluoride / acetonitrile / 3 h / 110 °C

2: triethylamine; sodium hydroxide / methanol; hexane; ethyl acetate / 20 °C

3: thionyl chloride / acetonitrile / 70 °C / Inert atmosphere

4: triethylamine / acetonitrile / 0.5 h / 20 °C

5: water; sodium hydrogencarbonate / methanol / 2 h / 50 °C

With thionyl chloride; tetrabutyl ammonium fluoride; water; sodium hydrogencarbonate; triethylamine; sodium hydroxide; In methanol; hexane; ethyl acetate; acetonitrile;
DOI:10.1016/j.ejmech.2011.06.023

Reference yield:

: 60462-19-3
methyl 4-(hydroxymethyl)cubane-1-carboxylate

: 1350821-91-8
4-(fluoromethyl)-N-(2-(4-(2-hydroxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)cubane-1-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / acetonitrile / 3 h / 110 °C

3: triethylamine; sodium hydroxide / methanol; hexane; ethyl acetate / 20 °C

4: thionyl chloride / acetonitrile / 70 °C / Inert atmosphere

5: triethylamine / acetonitrile / 0.5 h / 20 °C

6: water; sodium hydrogencarbonate / methanol / 2 h / 50 °C

With thionyl chloride; carbon tetrabromide; tetrabutyl ammonium fluoride; water; sodium hydrogencarbonate; triethylamine; triphenylphosphine; sodium hydroxide; In methanol; hexane; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1016/j.ejmech.2011.06.023