4-amino-5-phenyl-7-(β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine

Base Information

• Chemical Name: 4-amino-5-phenyl-7-(β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
• CAS No.: 1252857-91-2
• Molecular Formula: C₁₇H₁₈N₄O₄
• Molecular Weight: 342.354
• Mol file: 1252857-91-2.mol

Synonyms:4-amino-5-phenyl-7-(β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine

Chemical Property of 4-amino-5-phenyl-7-(β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-amino-5-phenyl-7-(β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine

There total 5 articles about 4-amino-5-phenyl-7-(β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

C38H30N4O7 → 4-amino-5-phenyl-7-(β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine (1252857-91-2)

Guidance literature:

With ammonia; In methanol; at 120 ℃; for 2h;

DOI:10.1016/j.bmcl.2016.07.041

Reference yield: 62.0%

5-Bromotubercidin (21193-80-6,21193-61-3) + phenylboronic acid (98-80-6) → 4-amino-5-phenyl-7-(β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine (1252857-91-2)

Guidance literature:

With trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; sodium carbonate; In water; acetonitrile; at 100 ℃; Inert atmosphere;

DOI:10.1016/j.ejmech.2018.12.050

Reference yield: 54.0%

5-iodotubercidin (24386-93-4) + phenylboronic acid (98-80-6) → 4-amino-5-phenyl-7-(β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine (1252857-91-2)

Guidance literature:

With trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; sodium carbonate; In water; acetonitrile; at 100 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jm2005173

upstream raw materials:

5-iodotubercidin

phenylboronic acid

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine