Technology Process of (4aS,10aR)-7-Isopropyl-6-methoxy-4a-methyl-1-phenylsulfanylmethyl-3,4,4a,9,10,10a-hexahydro-phenanthrene
There total 11 articles about (4aS,10aR)-7-Isopropyl-6-methoxy-4a-methyl-1-phenylsulfanylmethyl-3,4,4a,9,10,10a-hexahydro-phenanthrene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 80 percent / Al2Cl6 / CS2
2: 1.) 3,5-dinitroperbenzoic acid-methanesulfonic acid, 3.) NaH
3: 76 percent / EtSLi / hexamethylphosphoric acid triamide; tetrahydrofuran / Ambient temperature
4: Curtius degradation
5: 1.) LiAlH4 / 2.) Eschweiler-Clarke methylation
7: Cope elimination
8: m-CPBA
9: Et2Al-N-i-Pr2 / benzene; petroleum ether / 50 °C
10: n-Bu3P, CCl4 / 0 °C
11: tetrahydrofuran / Ambient temperature
With
tetrachloromethane; lithium aluminium tetrahydride; methanesulfonic acid; diisopropylamino diethylaluminium; aluminium chloride dimer; tributylphosphine; 3,5-dinitrobenzoperoxoic acid; sodium hydride; lithium thioethoxide; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; carbon disulfide; N,N,N,N,N,N-hexamethylphosphoric triamide; Petroleum ether; benzene;
DOI:10.1021/ja00523a067
- Guidance literature:
-
Multi-step reaction with 4 steps
1: m-CPBA
2: Et2Al-N-i-Pr2 / benzene; petroleum ether / 50 °C
3: n-Bu3P, CCl4 / 0 °C
4: tetrahydrofuran / Ambient temperature
With
tetrachloromethane; diisopropylamino diethylaluminium; tributylphosphine; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; Petroleum ether; benzene;
DOI:10.1021/ja00523a067
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 76 percent / EtSLi / hexamethylphosphoric acid triamide; tetrahydrofuran / Ambient temperature
2: Curtius degradation
3: 1.) LiAlH4 / 2.) Eschweiler-Clarke methylation
5: Cope elimination
6: m-CPBA
7: Et2Al-N-i-Pr2 / benzene; petroleum ether / 50 °C
8: n-Bu3P, CCl4 / 0 °C
9: tetrahydrofuran / Ambient temperature
With
tetrachloromethane; lithium aluminium tetrahydride; diisopropylamino diethylaluminium; tributylphosphine; lithium thioethoxide; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; Petroleum ether; benzene;
DOI:10.1021/ja00523a067
