tert-butyl 3a-(1-(tert-butoxycarbonyl)-1H-indol-3-yl)-3-(4-methoxybenzyloxy)-3,3a-dihydro-2H-furo[2,3-b]indole-8(8aH)-carboxylate

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Chemical Name:tert-butyl 3a-(1-(tert-butoxycarbonyl)-1H-indol-3-yl)-3-(4-methoxybenzyloxy)-3,3a-dihydro-2H-furo[2,3-b]indole-8(8aH)-carboxylate
CAS No.:1454598-39-0
Molecular Formula:C₃₆H₄₀N₂O₇
Molecular Weight:612.723
Hs Code.:

Synonyms:tert-butyl 3a-(1-(tert-butoxycarbonyl)-1H-indol-3-yl)-3-(4-methoxybenzyloxy)-3,3a-dihydro-2H-furo[2,3-b]indole-8(8aH)-carboxylate

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Chemical Property of tert-butyl 3a-(1-(tert-butoxycarbonyl)-1H-indol-3-yl)-3-(4-methoxybenzyloxy)-3,3a-dihydro-2H-furo[2,3-b]indole-8(8aH)-carboxylate

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Technology Process of tert-butyl 3a-(1-(tert-butoxycarbonyl)-1H-indol-3-yl)-3-(4-methoxybenzyloxy)-3,3a-dihydro-2H-furo[2,3-b]indole-8(8aH)-carboxylate

There total 7 articles about tert-butyl 3a-(1-(tert-butoxycarbonyl)-1H-indol-3-yl)-3-(4-methoxybenzyloxy)-3,3a-dihydro-2H-furo[2,3-b]indole-8(8aH)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1454598-38-9
C₃₆H₄₂N₂O₈

: 1454598-39-0
tert-butyl 3a-(1-(tert-butoxycarbonyl)-1H-indol-3-yl)-3-(4-methoxybenzyloxy)-3,3a-dihydro-2H-furo[2,3-b]indole-8(8aH)-carboxylate

Guidance literature:: With toluene-4-sulfonic acid; In methanol; at 20 ℃;
DOI:10.1002/chem.201204522

Reference yield:

: 33333-60-7
3-hydroxy-3-indolyl-2-oxindole

: 1454598-39-0
tert-butyl 3a-(1-(tert-butoxycarbonyl)-1H-indol-3-yl)-3-(4-methoxybenzyloxy)-3,3a-dihydro-2H-furo[2,3-b]indole-8(8aH)-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 6'-hydroxy-9-amino-9-deoxy-epi-quinidine; C₄₈H₂₉O₄P / chloroform / 96 h / 0 °C / Inert atmosphere

2: sodium tetrahydroborate / methanol / 1 h / 0 °C

3: dmap / dichloromethane / 0.5 h / 20 °C

4: sodium tetrahydroborate / methanol / 1 h / 0 °C

5: toluene-4-sulfonic acid / methanol / 20 °C

With dmap; sodium tetrahydroborate; 6'-hydroxy-9-amino-9-deoxy-epi-quinidine; C₄₈H₂₉O₄P; toluene-4-sulfonic acid; In methanol; dichloromethane; chloroform;
DOI:10.1002/chem.201204522

Reference yield:

: 1454598-13-0
(2S)-(4-methoxybenzyloxy)-2-((3R)-2-oxo-3,3'-biindol-3-yl)acetaldehyde

: 1454598-39-0
tert-butyl 3a-(1-(tert-butoxycarbonyl)-1H-indol-3-yl)-3-(4-methoxybenzyloxy)-3,3a-dihydro-2H-furo[2,3-b]indole-8(8aH)-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate / methanol / 1 h / 0 °C

2: dmap / dichloromethane / 0.5 h / 20 °C

3: sodium tetrahydroborate / methanol / 1 h / 0 °C

4: toluene-4-sulfonic acid / methanol / 20 °C

With dmap; sodium tetrahydroborate; toluene-4-sulfonic acid; In methanol; dichloromethane;
DOI:10.1002/chem.201204522