5'-deoxy-5'-iodo-2'-C-(fluoromethyl)uridine

Base Information

Chemical Name:5'-deoxy-5'-iodo-2'-C-(fluoromethyl)uridine
CAS No.:1613591-13-1
Molecular Formula:C₁₀H₁₂FIN₂O₅
Molecular Weight:386.119
Hs Code.:

Synonyms:5'-deoxy-5'-iodo-2'-C-(fluoromethyl)uridine

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Chemical Property of 5'-deoxy-5'-iodo-2'-C-(fluoromethyl)uridine

Chemical Property:

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Technology Process of 5'-deoxy-5'-iodo-2'-C-(fluoromethyl)uridine

There total 1 articles about 5'-deoxy-5'-iodo-2'-C-(fluoromethyl)uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 22224-41-5
1,3,5-tri-O-benzoyl-α-D-ribofuranoside

: 1613591-13-1
5'-deoxy-5'-iodo-2'-C-(fluoromethyl)uridine

Guidance literature:: Multi-step reaction with 13 steps

1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / acetonitrile / 12 h / Reflux

2.1: tetrahydrofuran / 1 h / -78 - 30 °C

2.2: 12 h / 20 °C

3.1: NOBSA / acetonitrile / 1.5 h / Reflux

3.2: 12 h / 60 - 70 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 0 - 20 °C

5.1: methanol; sodium methylate / dichloromethane / 2.5 h / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

6.2: 12 h / 20 °C

7.1: water; 4-methylmorpholine N-oxide; osmium(VIII) oxide / tetrahydrofuran / 24 h / 20 °C

8.1: sodium periodate / tetrahydrofuran; methanol; water / 2 h / 20 °C

8.2: 0.5 h / 0 - 20 °C

9.1: dmap / dichloromethane / 0.67 h / 0 - 20 °C

10.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 72 h / 70 - 80 °C

11.1: ammonium cerium (IV) nitrate / acetonitrile; water / 20 °C

12.1: boron trichloride / dichloromethane / 2 h / -70 °C

13.1: triphenylphosphine; pyridine; iodine / 12 h / 0 - 20 °C / Inert atmosphere

With pyridine; methanol; dmap; sodium periodate; osmium(VIII) oxide; ammonium cerium (IV) nitrate; tetrabutyl ammonium fluoride; water; iodine; sodium methylate; boron trichloride; sodium hydride; potassium carbonate; 4-methylmorpholine N-oxide; triphenylphosphine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1613591-13-1
5'-deoxy-5'-iodo-2'-C-(fluoromethyl)uridine

: 1613591-16-4
C₂₄H₁₉F₂IN₂O₇

Guidance literature:: Multi-step reaction with 3 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran; acetonitrile / 2 h / 60 - 70 °C

2: triethylamine tris(hydrogen fluoride); N-iodo-succinimide / acetonitrile / 2 h / 0 - 20 °C

3: dmap; triethylamine / dichloromethane / 12 h / 20 °C

With dmap; N-iodo-succinimide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine tris(hydrogen fluoride); triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;

Reference yield:

: 1613591-13-1
5'-deoxy-5'-iodo-2'-C-(fluoromethyl)uridine

: 1613591-17-5
C₃₁H₂₄F₂N₂O₉

Guidance literature:: Multi-step reaction with 4 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran; acetonitrile / 2 h / 60 - 70 °C

2: triethylamine tris(hydrogen fluoride); N-iodo-succinimide / acetonitrile / 2 h / 0 - 20 °C

3: dmap; triethylamine / dichloromethane / 12 h / 20 °C

4: 15-crown-5 / N,N-dimethyl-formamide / 24 h / 90 - 100 °C

With dmap; N-iodo-succinimide; 15-crown-5; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine tris(hydrogen fluoride); triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;