1-(3-methoxybenzyl)-N-(4-methyl-3-(morpholinosulfonyl)phenyl)-3-(p-tolyl)-1H-pyrazole-4-carboxamide

Base Information

Chemical Name:1-(3-methoxybenzyl)-N-(4-methyl-3-(morpholinosulfonyl)phenyl)-3-(p-tolyl)-1H-pyrazole-4-carboxamide
CAS No.:1609564-75-1
Molecular Formula:C₃₀H₃₂N₄O₅S
Molecular Weight:560.674
Hs Code.:

Synonyms:1-(3-methoxybenzyl)-N-(4-methyl-3-(morpholinosulfonyl)phenyl)-3-(p-tolyl)-1H-pyrazole-4-carboxamide

Suppliers and Price of 1-(3-methoxybenzyl)-N-(4-methyl-3-(morpholinosulfonyl)phenyl)-3-(p-tolyl)-1H-pyrazole-4-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
DY268
100mg
$ 1075.00

Tocris
DY268 ≥98%(HPLC)
10
$ 173.00

Tocris
DY268 ≥98%(HPLC)
50
$ 724.00

Cayman Chemical
DY 268
25mg
$ 281.00

Cayman Chemical
DY 268
5mg
$ 94.00

Cayman Chemical
DY 268
1mg
$ 25.00

Cayman Chemical
DY 268
10mg
$ 150.00

AK Scientific
1-[(3-Methoxyphenyl)methyl]-N-(4-methyl-3-morpholin-4-ylsulfonylphenyl)-3-(4-methylphenyl)pyrazole-4-carboxamide
1mg
$ 133.00

Total 1 raw suppliers

Chemical Property of 1-(3-methoxybenzyl)-N-(4-methyl-3-(morpholinosulfonyl)phenyl)-3-(p-tolyl)-1H-pyrazole-4-carboxamide

Chemical Property:

Density:1.30±0.1 g/cm3(Predicted)

Purity/Quality:

98% ^*data from raw suppliers

DY268 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses DY 268 is a potent farnesoid X receptor (FXR) antagonist.

Technology Process of 1-(3-methoxybenzyl)-N-(4-methyl-3-(morpholinosulfonyl)phenyl)-3-(p-tolyl)-1H-pyrazole-4-carboxamide

There total 5 articles about 1-(3-methoxybenzyl)-N-(4-methyl-3-(morpholinosulfonyl)phenyl)-3-(p-tolyl)-1H-pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 114500-32-2
4-methyl-3-(morpholine-4-sulfonyl)phenylamine

: 1609564-85-3
1-(3-methoxybenzyl)-3-(p-tolyl)-1H-pyrazole-4-carboxylic acid

: 1609564-75-1
1-(3-methoxybenzyl)-N-(4-methyl-3-(morpholinosulfonyl)phenyl)-3-(p-tolyl)-1H-pyrazole-4-carboxamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 6h; Inert atmosphere;
DOI:10.1016/j.bmc.2014.04.014

Reference yield:

: 1242014-95-4
ethyl 3-(p-tolyl)-1H-pyrazole-4-carboxylate

: 1609564-75-1
1-(3-methoxybenzyl)-N-(4-methyl-3-(morpholinosulfonyl)phenyl)-3-(p-tolyl)-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / acetonitrile / 16 h / 20 °C / Inert atmosphere

2: potassium hydroxide / water; ethanol / 3.5 h / 75 °C / Inert atmosphere

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 6 h / 20 °C / Inert atmosphere

With dmap; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In ethanol; dichloromethane; water; acetonitrile; 3: |Mitsunobu Displacement;
DOI:10.1016/j.bmc.2014.04.014

Reference yield:

: C₂₁H₂₂N₂O₃

: 1609564-75-1
1-(3-methoxybenzyl)-N-(4-methyl-3-(morpholinosulfonyl)phenyl)-3-(p-tolyl)-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / water; ethanol / 3.5 h / 75 °C / Inert atmosphere

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 6 h / 20 °C / Inert atmosphere

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In ethanol; dichloromethane; water; 2: |Mitsunobu Displacement;
DOI:10.1016/j.bmc.2014.04.014