(S)-[N-3-(4-(2-imidazol-1-yl-pyridin-5-yl)-3-fluoro phenyl)-2-oxo-5-oxazolidinyl]methyl acetamide

Base Information

• Chemical Name: (S)-[N-3-(4-(2-imidazol-1-yl-pyridin-5-yl)-3-fluoro phenyl)-2-oxo-5-oxazolidinyl]methyl acetamide
• CAS No.: 380381-17-9
• Molecular Formula: C₂₀H₁₈FN₅O₃
• Molecular Weight: 395.393

Synonyms:(S)-[N-3-(4-(2-imidazol-1-yl-pyridin-5-yl)-3-fluoro phenyl)-2-oxo-5-oxazolidinyl]methyl acetamide

Chemical Property of (S)-[N-3-(4-(2-imidazol-1-yl-pyridin-5-yl)-3-fluoro phenyl)-2-oxo-5-oxazolidinyl]methyl acetamide

Chemical Property:

Purity/Quality:

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Technology Process of (S)-[N-3-(4-(2-imidazol-1-yl-pyridin-5-yl)-3-fluoro phenyl)-2-oxo-5-oxazolidinyl]methyl acetamide

There total 2 articles about (S)-[N-3-(4-(2-imidazol-1-yl-pyridin-5-yl)-3-fluoro phenyl)-2-oxo-5-oxazolidinyl]methyl acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

N-({(5S)-3-[3-fluoro-4-(trimethylstannyl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide (188975-86-2) + 5-bromo-2-(1H-imidazol-1-yl)pyridine (380381-18-0) → (S)-[N-3-(4-(2-imidazol-1-yl-pyridin-5-yl)-3-fluoro phenyl)-2-oxo-5-oxazolidinyl]methyl acetamide (380381-17-9)

Guidance literature:

With lithium chloride; bis-triphenylphosphine-palladium(II) chloride; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 4h;

DOI:10.1016/j.bmc.2004.08.025

Reference yield:

→ (S)-[N-3-(4-(2-imidazol-1-yl-pyridin-5-yl)-3-fluoro phenyl)-2-oxo-5-oxazolidinyl]methyl acetamide (380381-17-9)

Guidance literature:

Reference yield:

(S)-[N-3-(4-(2-imidazol-1-yl-pyridin-5-yl)-3-fluoro phenyl)-2-oxo-5-oxazolidinyl]methyl acetamide (380381-17-9) → C18H16FN5O3

Guidance literature:

With pyridine; hydroxylamine; In pyridine; ethanol; at 20 - 100 ℃; for 10h;

upstream raw materials:

N-({(5S)-3-[3-fluoro-4-(trimethylstannyl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide

5-bromo-2-(1H-imidazol-1-yl)pyridine

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