ethyl 3-(4-phenylthiazol-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole-4-carboxylate

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Chemical Name:ethyl 3-(4-phenylthiazol-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole-4-carboxylate
CAS No.:1607441-20-2
Molecular Formula:C₂₁H₂₇N₃O₃SSi
Molecular Weight:429.615
Hs Code.:

Synonyms:ethyl 3-(4-phenylthiazol-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole-4-carboxylate

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Chemical Property of ethyl 3-(4-phenylthiazol-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole-4-carboxylate

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Technology Process of ethyl 3-(4-phenylthiazol-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole-4-carboxylate

There total 4 articles about ethyl 3-(4-phenylthiazol-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1607440-66-3
ethyl 3-(4-phenylthiazol-2-yl)-1H-pyrazole-4-carboxylate

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1607441-20-2
ethyl 3-(4-phenylthiazol-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole-4-carboxylate

Guidance literature:: ethyl 3-(4-phenylthiazol-2-yl)-1H-pyrazole-4-carboxylate; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.25h;

(2-trimethylethylsilylethoxy)methyl chloride; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

: 31877-30-2
ethyl 4-phenyl-1,3-thiazole-2-carboxylate

: 1607441-20-2
ethyl 3-(4-phenylthiazol-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran; toluene / 0.5 h / -50 °C

2.1: ethanol / 15 h / 80 °C

3.1: hydrazine hydrate / ethanol / 0.25 h

4.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

4.2: 16 h / 20 °C

With hydrazine hydrate; sodium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; toluene;

Reference yield:

: 1607441-14-4
ethyl 3-oxo-3-(4-phenylthiazol-2-yl)propanoate

: 1607441-20-2
ethyl 3-(4-phenylthiazol-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 15 h / 80 °C

2.1: hydrazine hydrate / ethanol / 0.25 h

3.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

3.2: 16 h / 20 °C

With hydrazine hydrate; sodium hydride; In tetrahydrofuran; ethanol;