6,7-dimethoxy-3-<4-(4-fluorobenzoyl)-piperidin-1-yl>-1-methyl-4-nitroisoquinoline

Base Information

Chemical Name:6,7-dimethoxy-3-<4-(4-fluorobenzoyl)-piperidin-1-yl>-1-methyl-4-nitroisoquinoline
CAS No.:116441-55-5
Molecular Formula:C₂₄H₂₄FN₃O₅
Molecular Weight:453.47
Hs Code.:

Synonyms:6,7-dimethoxy-3-<4-(4-fluorobenzoyl)-piperidin-1-yl>-1-methyl-4-nitroisoquinoline

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Chemical Property of 6,7-dimethoxy-3-<4-(4-fluorobenzoyl)-piperidin-1-yl>-1-methyl-4-nitroisoquinoline

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Technology Process of 6,7-dimethoxy-3-<4-(4-fluorobenzoyl)-piperidin-1-yl>-1-methyl-4-nitroisoquinoline

There total 2 articles about 6,7-dimethoxy-3-<4-(4-fluorobenzoyl)-piperidin-1-yl>-1-methyl-4-nitroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 56346-57-7
(4-fluorophenyl)-piperidin-4-ylmethanone

: 116441-42-0
6,7-dimethoxy-1-methyl-3-<(4-methylphenyl-sulfonyl)oxy>-4-nitroisoquinoline

: 116441-55-5
6,7-dimethoxy-3-<4-(4-fluorobenzoyl)-piperidin-1-yl>-1-methyl-4-nitroisoquinoline

Guidance literature:: With triethylamine; In toluene; for 12h; Heating;
DOI:10.1016/S0040-4020(01)85974-3

Reference yield:

: 113982-73-3
3-Hydroxy-6,7-dimethoxy-1-methyl-4-nitroisoquinoline

: 116441-55-5
6,7-dimethoxy-3-<4-(4-fluorobenzoyl)-piperidin-1-yl>-1-methyl-4-nitroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / triethylamine, 4-(N,N-dimethylamino)-piridine / CH₂Cl₂ / 5 h / Ambient temperature

2: 92 percent / triethylamine / toluene / 12 h / Heating

With dmap; triethylamine; In dichloromethane; toluene;
DOI:10.1016/S0040-4020(01)85974-3