methyl (4R)-1-[(2S)-2-cyclohexyl-2-(hept-6-en-1-ylamino)acetyl]-4-[(6-methoxy-7-vinylisoquinolin-1-yl)oxy]-L-prolinate

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Chemical Name:methyl (4R)-1-[(2S)-2-cyclohexyl-2-(hept-6-en-1-ylamino)acetyl]-4-[(6-methoxy-7-vinylisoquinolin-1-yl)oxy]-L-prolinate
CAS No.:1000064-35-6
Molecular Formula:C₃₃H₄₅N₃O₅
Molecular Weight:563.737
Hs Code.:

Synonyms:methyl (4R)-1-[(2S)-2-cyclohexyl-2-(hept-6-en-1-ylamino)acetyl]-4-[(6-methoxy-7-vinylisoquinolin-1-yl)oxy]-L-prolinate

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Chemical Property of methyl (4R)-1-[(2S)-2-cyclohexyl-2-(hept-6-en-1-ylamino)acetyl]-4-[(6-methoxy-7-vinylisoquinolin-1-yl)oxy]-L-prolinate

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Technology Process of methyl (4R)-1-[(2S)-2-cyclohexyl-2-(hept-6-en-1-ylamino)acetyl]-4-[(6-methoxy-7-vinylisoquinolin-1-yl)oxy]-L-prolinate

There total 1 articles about methyl (4R)-1-[(2S)-2-cyclohexyl-2-(hept-6-en-1-ylamino)acetyl]-4-[(6-methoxy-7-vinylisoquinolin-1-yl)oxy]-L-prolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1000064-14-1
(2S)-cyclohexyl(hept-6-en-1-ylamino)ethanoic acid

: 957752-61-3
C₁₈H₂₀N₂O₄

: 1000064-35-6
methyl (4R)-1-[(2S)-2-cyclohexyl-2-(hept-6-en-1-ylamino)acetyl]-4-[(6-methoxy-7-vinylisoquinolin-1-yl)oxy]-L-prolinate

Guidance literature:: (2S)-cyclohexyl(hept-6-en-1-ylamino)ethanoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane;

C₁₈H₂₀N₂O₄; In dichloromethane;
DOI:10.1021/jm900372w

Reference yield: 10.0%

: 1000064-35-6
methyl (4R)-1-[(2S)-2-cyclohexyl-2-(hept-6-en-1-ylamino)acetyl]-4-[(6-methoxy-7-vinylisoquinolin-1-yl)oxy]-L-prolinate

: 76-05-1
trifluoroacetic acid

: 1000063-87-5
(2R,4S,7S,14E)-7-cyclohexyl-23-methoxy-4-(methoxycarbonyl)-6-oxo-3,4,6,7,8,9,10,11,12,13-decahydro-2H-16,18-etheno-2,5-methanopyrido[3,2-r][1,5,8]oxadiazacyclononadecin-8-ium trifluoroacetate

Guidance literature:: With [1,3-bis-(2,4,6-trimethylphenyl)imidazolidin-2-yl]-(dichloro)[5-chloro-2-(propan-2-yloxy)benzylidene]ruthenium; In dichloromethane; at 100 ℃; Microwave irradiation;
DOI:10.1021/jm900372w