Z-(R)-1-[2-[[2-(3-Fluorophenyl)-2-(2-methylphenyl)ethenyl]oxy]ethyl]-3-piperidine carboxylic acid ethyl ester

Base Information

Chemical Name:Z-(R)-1-[2-[[2-(3-Fluorophenyl)-2-(2-methylphenyl)ethenyl]oxy]ethyl]-3-piperidine carboxylic acid ethyl ester
CAS No.:131029-38-4
Molecular Formula:C₂₅H₃₀FNO₃
Molecular Weight:411.517
Hs Code.:

Synonyms:Z-(R)-1-[2-[[2-(3-Fluorophenyl)-2-(2-methylphenyl)ethenyl]oxy]ethyl]-3-piperidine carboxylic acid ethyl ester

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Chemical Property of Z-(R)-1-[2-[[2-(3-Fluorophenyl)-2-(2-methylphenyl)ethenyl]oxy]ethyl]-3-piperidine carboxylic acid ethyl ester

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Technology Process of Z-(R)-1-[2-[[2-(3-Fluorophenyl)-2-(2-methylphenyl)ethenyl]oxy]ethyl]-3-piperidine carboxylic acid ethyl ester

There total 2 articles about Z-(R)-1-[2-[[2-(3-Fluorophenyl)-2-(2-methylphenyl)ethenyl]oxy]ethyl]-3-piperidine carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 127586-62-3
(R)-1-(2-hydroxyethyl)-3-piperidinecarboxylic acid ethyl ester

: 131029-38-4
Z-(R)-1-[2-[[2-(3-Fluorophenyl)-2-(2-methylphenyl)ethenyl]oxy]ethyl]-3-piperidine carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 68 percent / SOBr₂ / toluene / 2 h / 20 °C

2.1: NaH / toluene / 0.5 h / 20 °C

2.2: toluene / 1 h

With sulfurous dibromide; sodium hydride; In toluene; 1.1: Bromination / 2.1: Metallation / 2.2: Alkylation;
DOI:10.1021/jm981027k

Reference yield:

: 37675-19-7
(R)-ethyl piperidine-3-carboxylate hydrochloride

: 131029-38-4
Z-(R)-1-[2-[[2-(3-Fluorophenyl)-2-(2-methylphenyl)ethenyl]oxy]ethyl]-3-piperidine carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 74 percent / K₂CO₃; KI / acetone / 18 h / 20 °C

2.1: 68 percent / SOBr₂ / toluene / 2 h / 20 °C

3.1: NaH / toluene / 0.5 h / 20 °C

3.2: toluene / 1 h

With sulfurous dibromide; sodium hydride; potassium carbonate; potassium iodide; In acetone; toluene; 1.1: Alkylation / 2.1: Bromination / 3.1: Metallation / 3.2: Alkylation;
DOI:10.1021/jm981027k