cyclohexyl-[3-(4-fluorophenyl)-6-piperazin-1-yl-[2,4']bipyridinyl-2'-yl]-amine

Base Information

Chemical Name:cyclohexyl-[3-(4-fluorophenyl)-6-piperazin-1-yl-[2,4']bipyridinyl-2'-yl]-amine
CAS No.:1201673-01-9
Molecular Formula:C₂₆H₃₀FN₅
Molecular Weight:431.556
Hs Code.:

Synonyms:cyclohexyl-[3-(4-fluorophenyl)-6-piperazin-1-yl-[2,4']bipyridinyl-2'-yl]-amine

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Chemical Property of cyclohexyl-[3-(4-fluorophenyl)-6-piperazin-1-yl-[2,4']bipyridinyl-2'-yl]-amine

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Technology Process of cyclohexyl-[3-(4-fluorophenyl)-6-piperazin-1-yl-[2,4']bipyridinyl-2'-yl]-amine

There total 7 articles about cyclohexyl-[3-(4-fluorophenyl)-6-piperazin-1-yl-[2,4']bipyridinyl-2'-yl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1201674-84-1
4-[2'-cyclohexylamino-3-(4-fluorophenyl)-[2,4']bipyridinyl-6-yl]-piperazine-1-carboxylic acid tert-butyl ester

: 1201673-01-9
cyclohexyl-[3-(4-fluorophenyl)-6-piperazin-1-yl-[2,4']bipyridinyl-2'-yl]-amine

Guidance literature:: 4-[2'-cyclohexylamino-3-(4-fluorophenyl)-[2,4']bipyridinyl-6-yl]-piperazine-1-carboxylic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; for 1h;

With ammonium hydroxide; In water; acetonitrile;

Reference yield:

: 4-(6-bromopyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester

: 1201673-01-9
cyclohexyl-[3-(4-fluorophenyl)-6-piperazin-1-yl-[2,4']bipyridinyl-2'-yl]-amine

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; acetonitrile / 90 °C / Inert atmosphere

2: bromine / dichloromethane / 0.17 h

3: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 0.5 h / 120 °C / Microwave irradiation

4: sodium t-butanolate / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 1 h / 130 °C / Microwave irradiation

5: trifluoroacetic acid / dichloromethane / 1 h

With bromine; sodium carbonate; trifluoroacetic acid; sodium t-butanolate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; acetonitrile;

Reference yield:

: 1201674-79-4
4-(2'-chloro[2,4']bipyridinyl-6-yl)piperazine-1-carboxylic acid tert-butyl ester

: 1201673-01-9
cyclohexyl-[3-(4-fluorophenyl)-6-piperazin-1-yl-[2,4']bipyridinyl-2'-yl]-amine

Guidance literature:: Multi-step reaction with 4 steps

1: bromine / dichloromethane / 0.17 h

2: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 0.5 h / 120 °C / Microwave irradiation

3: sodium t-butanolate / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 1 h / 130 °C / Microwave irradiation

4: trifluoroacetic acid / dichloromethane / 1 h

With bromine; sodium carbonate; trifluoroacetic acid; sodium t-butanolate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water;