(E)-(1S,10S,21R)-21-(3-chloro-benzyl)-7,7-cyclopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraaza-bicyclo[8.7.6]-tricos-16-ene-3,6,9,19,22-pentaone

Base Information

Chemical Name:(E)-(1S,10S,21R)-21-(3-chloro-benzyl)-7,7-cyclopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraaza-bicyclo[8.7.6]-tricos-16-ene-3,6,9,19,22-pentaone
CAS No.:1196992-75-2
Molecular Formula:C₂₅H₂₉ClN₄O₆S₂
Molecular Weight:581.113
Hs Code.:

Synonyms:(E)-(1S,10S,21R)-21-(3-chloro-benzyl)-7,7-cyclopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraaza-bicyclo[8.7.6]-tricos-16-ene-3,6,9,19,22-pentaone

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Chemical Property of (E)-(1S,10S,21R)-21-(3-chloro-benzyl)-7,7-cyclopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraaza-bicyclo[8.7.6]-tricos-16-ene-3,6,9,19,22-pentaone

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Technology Process of (E)-(1S,10S,21R)-21-(3-chloro-benzyl)-7,7-cyclopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraaza-bicyclo[8.7.6]-tricos-16-ene-3,6,9,19,22-pentaone

There total 3 articles about (E)-(1S,10S,21R)-21-(3-chloro-benzyl)-7,7-cyclopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraaza-bicyclo[8.7.6]-tricos-16-ene-3,6,9,19,22-pentaone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1196992-74-1
(6S,9R,13S)-9-(3-chloro-benzyl)-13-((E)-4-tritylsulfanyl-but-1-enyl)-6-tritylsulfanylmethyl-14-oxa-4,7,10,17-tetraaza-spiro[2.15]octadecane-5,8,11,15,18-pentaone

: 1196992-75-2
(E)-(1S,10S,21R)-21-(3-chloro-benzyl)-7,7-cyclopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraaza-bicyclo[8.7.6]-tricos-16-ene-3,6,9,19,22-pentaone

Guidance literature:: With iodine; In methanol; dichloromethane; for 1.5h;

Reference yield:

: 1196992-72-9
[(1-{(S)-2-[(R)-3-(3-chloro-phenyl)-2-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-propionylamino]-3-tritylsulfanyl-propionylamino}-cyclopropanecarbonyl)-amino]-acetic acid methyl ester

: 1196992-75-2
(E)-(1S,10S,21R)-21-(3-chloro-benzyl)-7,7-cyclopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraaza-bicyclo[8.7.6]-tricos-16-ene-3,6,9,19,22-pentaone

Guidance literature:: Multi-step reaction with 3 steps

1: water; lithium hydroxide / tetrahydrofuran / 0 °C

2: dmap; 2-methyl-6-nitrobenzoic anhydride / dichloromethane / 20 °C

3: iodine / dichloromethane; methanol / 1.5 h

With dmap; 2-methyl-6-nitrobenzoic anhydride; water; iodine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1196992-73-0
[(1-{(S)-2-[(R)-3-(3-chloro-phenyl)-2-((E)-(S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoylamino)-propionylamino]-3-tritylsulfanyl-propionylamino}-cyclopropanecarbonyl)-amino]-acetic acid

: 1196992-75-2
(E)-(1S,10S,21R)-21-(3-chloro-benzyl)-7,7-cyclopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraaza-bicyclo[8.7.6]-tricos-16-ene-3,6,9,19,22-pentaone

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; 2-methyl-6-nitrobenzoic anhydride / dichloromethane / 20 °C

2: iodine / dichloromethane; methanol / 1.5 h

With dmap; 2-methyl-6-nitrobenzoic anhydride; iodine; In methanol; dichloromethane;