Technology Process of 3-(3-benzyl-1-phenyl-1H-indol-5-yl)propanoic acid
There total 9 articles about 3-(3-benzyl-1-phenyl-1H-indol-5-yl)propanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium on activated charcoal; hydrogen;
In
methanol;
at 20 ℃;
DOI:10.1021/jm500494y
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: palladium diacetate; tris-(o-tolyl)phosphine; triethylamine / 5 h / 120 °C / Sealed tube
2.1: sodium hydroxide / methanol; water; tetrahydrofuran / Heating
2.2: pH 1
3.1: palladium on activated charcoal; hydrogen / methanol / 20 °C
With
palladium on activated charcoal; hydrogen; palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; sodium hydroxide;
In
tetrahydrofuran; methanol; water;
1.1: |Heck Reaction;
DOI:10.1021/jm500494y
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: copper(I) bromide; potassium carbonate; potassium hydroxide; copper diacetate / 140 °C
2.1: aluminum (III) chloride / dichloromethane / 1 h / 20 °C
2.2: 3 h / 20 °C
3.1: sodium tetrahydroborate / methanol / 1 h / 20 °C / Cooling with ice
3.2: Cooling with ice
4.1: tin(IV) chloride; triethylsilane / dichloromethane / 1 h / -78 °C
5.1: palladium diacetate; tris-(o-tolyl)phosphine; triethylamine / 5 h / 120 °C / Sealed tube
6.1: sodium hydroxide / methanol; water; tetrahydrofuran / Heating
6.2: pH 1
7.1: palladium on activated charcoal; hydrogen / methanol / 20 °C
With
triethylsilane; aluminum (III) chloride; sodium tetrahydroborate; palladium on activated charcoal; hydrogen; copper diacetate; palladium diacetate; tin(IV) chloride; potassium carbonate; triethylamine; tris-(o-tolyl)phosphine; potassium hydroxide; copper(I) bromide; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water;
2.1: |Friedel-Crafts Acylation / 2.2: |Friedel-Crafts Acylation / 5.1: |Heck Reaction;
DOI:10.1021/jm500494y
