Technology Process of 1-(3,5-dimethylpiperidin-1-yl)-2,2-dimethyl-3-phenyl-3-(2,4,6-trimethoxyphenyl)propan-1-one
There total 3 articles about 1-(3,5-dimethylpiperidin-1-yl)-2,2-dimethyl-3-phenyl-3-(2,4,6-trimethoxyphenyl)propan-1-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C20H24O5;
With
2-chloro-1,3-dimethylimidazolinium chloride; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 20 ℃;
for 0.166667h;
cis-3,5-dimethylpiperidine;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: boron trifluoride diethyl etherate / dichloromethane / 2 h / 0 - 20 °C
2: lithium hydroxide; water / tetrahydrofuran; methanol / 1 h / 150 °C / Microwave irradiation; Sealed tube
3: 2-chloro-1,3-dimethylimidazolinium chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 20 °C
With
boron trifluoride diethyl etherate; water; 2-chloro-1,3-dimethylimidazolinium chloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: lithium hydroxide; water / tetrahydrofuran; methanol / 1 h / 150 °C / Microwave irradiation; Sealed tube
2: 2-chloro-1,3-dimethylimidazolinium chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 20 °C
With
water; 2-chloro-1,3-dimethylimidazolinium chloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane;
