N₁-[4-cyano-3-(trifluoromethyl)phenyl]-(2R)-2-hydroxy-3-[(3-isothiocyanatophenyl)sulfanyl]-2-methylpropanamide

Base Information

• Chemical Name: N₁-[4-cyano-3-(trifluoromethyl)phenyl]-(2R)-2-hydroxy-3-[(3-isothiocyanatophenyl)sulfanyl]-2-methylpropanamide
• CAS No.: 247090-54-6
• Molecular Formula: C₁₉H₁₄F₃N₃O₂S₂
• Molecular Weight: 437.466

Synonyms:N₁-[4-cyano-3-(trifluoromethyl)phenyl]-(2R)-2-hydroxy-3-[(3-isothiocyanatophenyl)sulfanyl]-2-methylpropanamide

Chemical Property of N₁-[4-cyano-3-(trifluoromethyl)phenyl]-(2R)-2-hydroxy-3-[(3-isothiocyanatophenyl)sulfanyl]-2-methylpropanamide

Chemical Property:

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Technology Process of N₁-[4-cyano-3-(trifluoromethyl)phenyl]-(2R)-2-hydroxy-3-[(3-isothiocyanatophenyl)sulfanyl]-2-methylpropanamide

There total 3 articles about N₁-[4-cyano-3-(trifluoromethyl)phenyl]-(2R)-2-hydroxy-3-[(3-isothiocyanatophenyl)sulfanyl]-2-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

thiophosgene (463-71-8) + N1-[4-cyano-3-(trifluoromethyl)phenyl]-(2R)-3-[(3-aminophenyl)sulfanyl]-2-hydroxy-2-methylpropanamide (247090-60-4) → N1-[4-cyano-3-(trifluoromethyl)phenyl]-(2R)-2-hydroxy-3-[(3-isothiocyanatophenyl)sulfanyl]-2-methylpropanamide (247090-54-6)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; chloroform; ethyl acetate; for 3h;

DOI:10.1021/jm990027x

Reference yield:

3-aminothiophenol (22948-02-3) → N1-[4-cyano-3-(trifluoromethyl)phenyl]-(2R)-2-hydroxy-3-[(3-isothiocyanatophenyl)sulfanyl]-2-methylpropanamide (247090-54-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent

2: 99 percent / aq. NaHCO₃ / CHCl₃; CH₂Cl₂; ethyl acetate / 3 h

With sodium hydrogencarbonate; In dichloromethane; chloroform; ethyl acetate; 2: isothiocyanation;

DOI:10.1021/jm990027x

Reference yield:

4-amino-2-trifluoromethylbenzonitrile (654-70-6) → N1-[4-cyano-3-(trifluoromethyl)phenyl]-(2R)-2-hydroxy-3-[(3-isothiocyanatophenyl)sulfanyl]-2-methylpropanamide (247090-54-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent

2: 99 percent / aq. NaHCO₃ / CHCl₃; CH₂Cl₂; ethyl acetate / 3 h

With sodium hydrogencarbonate; In dichloromethane; chloroform; ethyl acetate; 2: isothiocyanation;

DOI:10.1021/jm990027x

upstream raw materials:

thiophosgene

N₁-[4-cyano-3-(trifluoromethyl)phenyl]-(2R)-3-[(3-aminophenyl)sulfanyl]-2-hydroxy-2-methylpropanamide

3-aminothiophenol

4-amino-2-trifluoromethylbenzonitrile

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