(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-1-yl)(phenyl)methanone

Base Information

• Chemical Name: (2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-1-yl)(phenyl)methanone
• CAS No.: 102451-10-5
• Molecular Formula: C₁₄H₁₂N₂O
• Molecular Weight: 224.262
• Mol file: 102451-10-5.mol

Synonyms:(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-1-yl)(phenyl)methanone

Chemical Property of (2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-1-yl)(phenyl)methanone

Chemical Property:

Purity/Quality:

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Technology Process of (2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-1-yl)(phenyl)methanone

There total 1 articles about (2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-1-yl)(phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

7-azaindoline (10592-27-5) + benzoic acid (65-85-0,8013-63-6) → (2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-1-yl)(phenyl)methanone (102451-10-5)

Guidance literature:

benzoic acid; With N-Bromosuccinimide; triphenylphosphine; In dichloromethane; at 0 ℃; for 0.5h;

7-azaindoline; With triethylamine; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1080/00397911.2020.1747631

Reference yield: 58.0%

(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-1-yl)(phenyl)methanone (102451-10-5) + 1-(benzyloxy)-4-(1,1,1-trifluoroprop-2-en-2-yl)benzene → (2-(3,3-difluoro-2-phenylallyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-1-yl)(phenyl)methanone

Guidance literature:

With Quinuclidine; [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate; sodium hydrogencarbonate; In acetonitrile; at 20 ℃; for 48h; Inert atmosphere; Irradiation; Sealed tube;

DOI:10.1021/acs.orglett.1c00546

upstream raw materials:

7-azaindoline

benzoic acid