2-BENZYL-2,5-DIAZA-BICYCLO[2,2,1]HEPTANE

Base Information

• Chemical Name: 2-BENZYL-2,5-DIAZA-BICYCLO[2,2,1]HEPTANE
• CAS No.: 114086-14-5
• Molecular Formula: C12H16N2
• Molecular Weight: 188.27
• Hs Code.: 2933990090
• Mol file: 114086-14-5.mol

Synonyms:2-(Phenylmethyl)-2,5-diazabicyclo[2.2.1]heptane;2-Benzyl-2,5-diazabicyclo[2.2.1]heptane;

Chemical Property of 2-BENZYL-2,5-DIAZA-BICYCLO[2,2,1]HEPTANE

Chemical Property:

• Boiling Point: 291 °C at 760 mmHg
• PKA: 10.02±0.20(Predicted)
• Flash Point: 128.1 °C
• PSA: 15.27000
• Density: 1.103 g/cm³
• LogP: 1.49940

Purity/Quality:

97% ^*data from raw suppliers

2-benzyl-2,5-diazabicyclo[2,2,1]heptane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BENZYL-2,5-DIAZA-BICYCLO[2,2,1]HEPTANE

There total 2 articles about 2-BENZYL-2,5-DIAZA-BICYCLO[2,2,1]HEPTANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-benzyl-5-benzyloxycarbonyl-2,5-diazabicyclo[2.2.1]heptane (125043-95-0) → 5-phenylmethyl-2,5-diazabicyclo[2.2.1.]heptane (114086-14-5)

Guidance literature:

In methanol; hydrogen bromide; acetic acid;

Reference yield:

→ 5-phenylmethyl-2,5-diazabicyclo[2.2.1.]heptane (114086-14-5)

Guidance literature:

(yield)76percent;

Reference yield: 98.0%

di-tert-butyl dicarbonate (24424-99-5) + 5-phenylmethyl-2,5-diazabicyclo[2.2.1.]heptane (114086-14-5) → tert-butyl 5-benzyl-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate

Guidance literature:

With lanthanum(III) nitrate; at 20 ℃; for 0.05h;

DOI:10.1016/j.tetlet.2006.09.081

upstream raw materials:

2-benzyl-5-benzyloxycarbonyl-2,5-diazabicyclo[2.2.1]heptane

Downstream raw materials:

2-benzyl-5-benzyloxycarbonyl-2,5-diazabicyclo[2.2.1]heptane

5-Benzyl-2,5-diazabicyclo[2.2.1]heptane-2-carboxylic acid 4-(5-trifluoromethylpyridin-2-yloxy)-phenyl ester

2-Benzyl-5-cyanomethyl-2,5-diazabicyclo[2.2.1]heptane

5-Phenyl-2-p-tosyl-2,5-diazabicyclo[2.2.1]heptane