(3R,4S)-4-(N-acryloyl-N-methylamino)-3-[(tert-butyl)dimethylsiloxy]-5-phenylpent-1-ene

Base Information

Chemical Name:(3R,4S)-4-(N-acryloyl-N-methylamino)-3-[(tert-butyl)dimethylsiloxy]-5-phenylpent-1-ene
CAS No.:894406-82-7
Molecular Formula:C₂₁H₃₃NO₂Si
Molecular Weight:359.584
Hs Code.:

Synonyms:(3R,4S)-4-(N-acryloyl-N-methylamino)-3-[(tert-butyl)dimethylsiloxy]-5-phenylpent-1-ene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4S)-4-(N-acryloyl-N-methylamino)-3-[(tert-butyl)dimethylsiloxy]-5-phenylpent-1-ene

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Technology Process of (3R,4S)-4-(N-acryloyl-N-methylamino)-3-[(tert-butyl)dimethylsiloxy]-5-phenylpent-1-ene

There total 7 articles about (3R,4S)-4-(N-acryloyl-N-methylamino)-3-[(tert-butyl)dimethylsiloxy]-5-phenylpent-1-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.4%

: 894406-81-6
(3R,4S)-3-[(tert-butyl)dimethylsiloxy]-4-[N-methyl-N-(2-nitrobenzenesulfonyl)amino]-5-phenylpent-1-ene

: 814-68-6,25189-84-8
acryloyl chloride

: 894406-82-7
(3R,4S)-4-(N-acryloyl-N-methylamino)-3-[(tert-butyl)dimethylsiloxy]-5-phenylpent-1-ene

Guidance literature:: (3R,4S)-3-[(tert-butyl)dimethylsiloxy]-4-[N-methyl-N-(2-nitrobenzenesulfonyl)amino]-5-phenylpent-1-ene; With lithium hydroxide; mercaptoacetic acid; In N,N-dimethyl-formamide;

acryloyl chloride; With triethylamine; In dichloromethane; cooling;
DOI:10.1021/jo060202z

Reference yield:

: [(1S,2R)-1-Benzyl-2-(tert-butyl-dimethyl-silanyloxy)-but-3-enyl]-methyl-amine

: 814-68-6,25189-84-8
acryloyl chloride

: 894406-82-7
(3R,4S)-4-(N-acryloyl-N-methylamino)-3-[(tert-butyl)dimethylsiloxy]-5-phenylpent-1-ene

Guidance literature:: With triethylamine; In dichloromethane;
DOI:10.1016/j.tetlet.2005.04.057

Reference yield:

: 894406-80-5
(3R,4S)-3-[(tert-butyl)dimethylsilyloxy]-4-[N-(2-nitrobenzenesulfonyl)amino]-5-phenylpent-1-ene

: 894406-82-7
(3R,4S)-4-(N-acryloyl-N-methylamino)-3-[(tert-butyl)dimethylsiloxy]-5-phenylpent-1-ene

Guidance literature:: Multi-step reaction with 3 steps

1: 95.4 percent / K₂CO₃ / dimethylformamide / 20 °C

2: LiOH*H₂O; HSCH₂CO₂H / dimethylformamide / 20 °C

3: 256 mg / Et₃N / CH₂Cl₂ / 0 °C

With lithium hydroxide; potassium carbonate; mercaptoacetic acid; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo060390t