7-(5-Bromo-2-trifluoromethoxy-phenyl)-1-ethyl-4,4,6-trimethyl-3,4-dihydro-1H-quinolin-2-one

Base Information

Chemical Name:7-(5-Bromo-2-trifluoromethoxy-phenyl)-1-ethyl-4,4,6-trimethyl-3,4-dihydro-1H-quinolin-2-one
CAS No.:932368-03-1
Molecular Formula:C₂₁H₂₁BrF₃NO₂
Molecular Weight:456.302
Hs Code.:

Synonyms:7-(5-Bromo-2-trifluoromethoxy-phenyl)-1-ethyl-4,4,6-trimethyl-3,4-dihydro-1H-quinolin-2-one

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Chemical Property of 7-(5-Bromo-2-trifluoromethoxy-phenyl)-1-ethyl-4,4,6-trimethyl-3,4-dihydro-1H-quinolin-2-one

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Technology Process of 7-(5-Bromo-2-trifluoromethoxy-phenyl)-1-ethyl-4,4,6-trimethyl-3,4-dihydro-1H-quinolin-2-one

There total 1 articles about 7-(5-Bromo-2-trifluoromethoxy-phenyl)-1-ethyl-4,4,6-trimethyl-3,4-dihydro-1H-quinolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 932368-02-0
1-Ethyl-4,4,6-trimethyl-7-(2-trifluoromethoxy-phenyl)-3,4-dihydro-1H-quinolin-2-one

: 932368-03-1
7-(5-Bromo-2-trifluoromethoxy-phenyl)-1-ethyl-4,4,6-trimethyl-3,4-dihydro-1H-quinolin-2-one

: C₂₁H₂₀Br₂F₃NO₂

Guidance literature:: With iron(III) chloride; bromine; In nitromethane; at 20 ℃;

Reference yield: 26.0%

: 932368-03-1
7-(5-Bromo-2-trifluoromethoxy-phenyl)-1-ethyl-4,4,6-trimethyl-3,4-dihydro-1H-quinolin-2-one

: 927-74-2
3-Butyn-1-ol

: 932368-26-8
1-Ethyl-7-[5-(4-hydroxy-but-1-ynyl)-2-trifluoromethoxy-phenyl]-4,4,6-trimethyl-3,4-dihydro-1H-quinolin-2-one

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 0.25h; Microwave irradiation;

Reference yield:

: 932368-03-1
7-(5-Bromo-2-trifluoromethoxy-phenyl)-1-ethyl-4,4,6-trimethyl-3,4-dihydro-1H-quinolin-2-one

: [3-(1-Ethyl-4,4,6-trimethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-7-yl)-4-trifluoromethoxy-phenyl]-propynoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: Pd(PPh₃)4 / 1-methyl-pyrrolidin-2-one / 0.25 h / 120 °C / microwave irradiation

2: 55 percent / TEMPO; NaClO₂ / acetonitrile; aq. phosphate buffer

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium chlorite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1-methyl-pyrrolidin-2-one; phosphate buffer; acetonitrile; 1: Sonogashira coupling;
DOI:10.1016/j.bmcl.2007.01.049