ethyl (4-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl)propylphosphinate

Base Information

Chemical Name:ethyl (4-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl)propylphosphinate
CAS No.:1606169-15-6
Molecular Formula:C₂₁H₂₃N₄O₄P
Molecular Weight:426.412
Hs Code.:

Synonyms:ethyl (4-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl)propylphosphinate

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Chemical Property of ethyl (4-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl)propylphosphinate

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Technology Process of ethyl (4-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl)propylphosphinate

There total 4 articles about ethyl (4-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl)propylphosphinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 915069-51-1
4-chloro-6-(3-nitrophenyl)-pyrimidine

: 1606169-06-5
ethyl (4-aminophenyl)propylphosphinate

: 1606169-15-6
ethyl (4-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl)propylphosphinate

Guidance literature:: ethyl (4-aminophenyl)propylphosphinate; With hydrogenchloride; In 1,4-dioxane; ethanol; water;

4-chloro-6-(3-nitrophenyl)-pyrimidine; In 1,4-dioxane; ethanol; water; isopropyl alcohol; Reflux;
DOI:10.1021/jm401742r

Reference yield:

: 104902-88-7
Monoethyl propylphosphonite

: 1606169-15-6
ethyl (4-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl)propylphosphinate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 20 h / Inert atmosphere; Reflux

2.1: tin(ll) chloride / ethanol / 4 h / Reflux

3.1: hydrogenchloride / ethanol; water; 1,4-dioxane

3.2: Reflux

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; tin(ll) chloride; In 1,4-dioxane; ethanol; water; toluene;
DOI:10.1021/jm401742r

Reference yield:

: 1606169-67-8
ethyl (4-nitrophenyl)propylphosphinate

: 1606169-15-6
ethyl (4-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}phenyl)propylphosphinate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tin(ll) chloride / ethanol / 4 h / Reflux

2.1: hydrogenchloride / ethanol; water; 1,4-dioxane

2.2: Reflux

With hydrogenchloride; tin(ll) chloride; In 1,4-dioxane; ethanol; water;
DOI:10.1021/jm401742r