methyl 2-((R)-2-((tert-butoxycarbonyl)amino)-2-(4-chlorophenyl)acetamido)-3-methylbutanoate

Base Information

Chemical Name:methyl 2-((R)-2-((tert-butoxycarbonyl)amino)-2-(4-chlorophenyl)acetamido)-3-methylbutanoate
CAS No.:1239906-50-3
Molecular Formula:C₁₉H₂₇ClN₂O₅
Molecular Weight:398.887
Hs Code.:

Synonyms:methyl 2-((R)-2-((tert-butoxycarbonyl)amino)-2-(4-chlorophenyl)acetamido)-3-methylbutanoate

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Chemical Property of methyl 2-((R)-2-((tert-butoxycarbonyl)amino)-2-(4-chlorophenyl)acetamido)-3-methylbutanoate

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Technology Process of methyl 2-((R)-2-((tert-butoxycarbonyl)amino)-2-(4-chlorophenyl)acetamido)-3-methylbutanoate

There total 2 articles about methyl 2-((R)-2-((tert-butoxycarbonyl)amino)-2-(4-chlorophenyl)acetamido)-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1239906-34-3
C₁₃H₁₆BrClN₂O₄

: 6306-52-1
L-valine methylester hydrochloride

: 1239906-50-3
methyl 2-((R)-2-((tert-butoxycarbonyl)amino)-2-(4-chlorophenyl)acetamido)-3-methylbutanoate

Guidance literature:: With N-iodo-succinimide; oxygen; potassium carbonate; In 1,2-dimethoxyethane; water; at 0 ℃; for 24h;
DOI:10.1021/ol502089v

Reference yield:

: 779342-75-5
tert-butyl 4-chlorobenzylidenecarbamate

: 1239906-50-3
methyl 2-((R)-2-((tert-butoxycarbonyl)amino)-2-(4-chlorophenyl)acetamido)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: CHF₃O₃S*C₃₄H₃₀N₄ / toluene / 48 h / -20 °C

2: N-iodo-succinimide; water; potassium carbonate / tetrahydrofuran / 48 h / 0 °C

With N-iodo-succinimide; CHF₃O₃S*C₃₄H₃₀N₄; water; potassium carbonate; In tetrahydrofuran; toluene; 1: Henry reaction;
DOI:10.1038/nature09125