2-amino-N¹-{1-benzylcarbamoyl-1-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-butyl}-N⁴,N⁴-dimethyl-succinamide

Base Information

• Chemical Name: 2-amino-N¹-{1-benzylcarbamoyl-1-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-butyl}-N⁴,N⁴-dimethyl-succinamide
• CAS No.: 872984-02-6
• Molecular Formula: C₃₆H₅₀N₄O₄Si
• Molecular Weight: 630.903

Synonyms:2-amino-N¹-{1-benzylcarbamoyl-1-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-butyl}-N⁴,N⁴-dimethyl-succinamide

Chemical Property of 2-amino-N¹-{1-benzylcarbamoyl-1-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-butyl}-N⁴,N⁴-dimethyl-succinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-amino-N¹-{1-benzylcarbamoyl-1-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-butyl}-N⁴,N⁴-dimethyl-succinamide

There total 8 articles about 2-amino-N¹-{1-benzylcarbamoyl-1-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-butyl}-N⁴,N⁴-dimethyl-succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-((1S)-1-{1-benzylcarbamoyl-1-[2-(tert-butyldiphenylsiloxy)ethyl]butylcarbamoyl}-3-dimethylamino-3-oxopropyl)carbamic acid benzyl ester (872983-47-6) → 2-amino-N1-{1-benzylcarbamoyl-1-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-butyl}-N4,N4-dimethyl-succinamide (872984-02-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃;

DOI:10.1016/j.bmc.2005.08.019

Reference yield:

3-amino-3-propyldihydrofuran-2-one (872983-41-0) → 2-amino-N1-{1-benzylcarbamoyl-1-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-butyl}-N4,N4-dimethyl-succinamide (872984-02-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 90 percent / 2-phenylbenzoxazole; ethyldiisopropylamine / CH₂Cl₂ / 0 °C

2: 1.22 g / lithium hydroxide / tetrahydrofuran; H₂O / 0 °C

3: 1.63 g / imidazole / CH₂Cl₂ / 0 °C

4: 1.55 g / 1-hydroxy-1H-benzotriazole; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl; triethylamine / CH₂Cl₂ / 0 °C

5: 100 percent / H₂ / Pd-C / methanol / 20 °C

With 1H-imidazole; lithium hydroxide; 2-phenylbenzo[d]oxazole; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1016/j.bmc.2005.08.019

Reference yield:

2-amino-2-(2-hydroxy-ethyl)-pentanoic acid → 2-amino-N1-{1-benzylcarbamoyl-1-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-butyl}-N4,N4-dimethyl-succinamide (872984-02-6)

Guidance literature:

Multi-step reaction with 6 steps

1: 2.4 g / hydrochloric acid / 16 h / Heating

2: 90 percent / 2-phenylbenzoxazole; ethyldiisopropylamine / CH₂Cl₂ / 0 °C

3: 1.22 g / lithium hydroxide / tetrahydrofuran; H₂O / 0 °C

4: 1.63 g / imidazole / CH₂Cl₂ / 0 °C

5: 1.55 g / 1-hydroxy-1H-benzotriazole; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl; triethylamine / CH₂Cl₂ / 0 °C

6: 100 percent / H₂ / Pd-C / methanol / 20 °C

With 1H-imidazole; hydrogenchloride; lithium hydroxide; 2-phenylbenzo[d]oxazole; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1016/j.bmc.2005.08.019

upstream raw materials:

N-((1S)-1-{1-benzylcarbamoyl-1-[2-(tert-butyldiphenylsiloxy)ethyl]butylcarbamoyl}-3-dimethylamino-3-oxopropyl)carbamic acid benzyl ester

3-amino-3-propyldihydrofuran-2-one

2-amino-2-(2-hydroxy-ethyl)-pent-4-enoic acid

[(S)-2-Dimethylcarbamoyl-1-(2-oxo-3-propyl-tetrahydro-furan-3-ylcarbamoyl)-ethyl]-carbamic acid benzyl ester

Downstream raw materials:

(4S)-4-((1S)-1-{1-benzylcarbamoyl-1-[2-(tert-butyldiphenylsiloxy)ethyl]butylcarbamoyl}-3-dimethylamino-3-oxopropylcarbamoyl)-4-(benzyloxycarbonylamino)butyric acid benzyl ester

[(1S)-1-((1S)-1-{1-benzylcarbamoyl-1-[2-(tert-butyldiphenylsiloxy)ethyl]butylcarbamoyl}-3-dimethylamino-3-oxopropylcarbamoyl)ethyl]carbamic acid benzyl ester

(3S)-N-((1S)-1-{1-benzylcarbamoyl-1-[2-(tert-butyldiphenylsiloxy)ethyl]butylcarbamoyl}-3-dimethylamino-3-oxopropyl)-3-(benzyloxycarbonylamino)succinamic acid benzyl ester

[(1S)-1-((1S)-1-{1-benzylcarbamoyl-1-[2-(tert-butyldiphenylsiloxy)ethyl]butylcarbamoyl}-3-dimethylamino-3-oxopropylcarbamoyl)-2,2-dimethylpropyl]carbamic acid benzyl ester

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