Technology Process of (1R,2S)-15N1,N2,N2-tribenzyl-1-(4-fluorophenyl)-3-methylbutane-1,2-diamine
There total 5 articles about (1R,2S)-15N1,N2,N2-tribenzyl-1-(4-fluorophenyl)-3-methylbutane-1,2-diamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(1S,2S)-2-(dibenzylamino)-1-(4-fluorophenyl)-3-methylbutan-1-ol;
With
methanesulfonyl chloride; triethylamine;
In
toluene;
at 0 ℃;
for 0.25h;
15N-benzylamine;
In
toluene;
at 0 - 20 ℃;
for 12h;
DOI:10.1016/j.tetlet.2012.11.079
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: diethyl ether; tetrahydrofuran / 1 h / 0 °C
2.1: triethylamine; methanesulfonyl chloride / toluene / 0.25 h / 0 °C
2.2: 12 h / 0 - 20 °C
With
methanesulfonyl chloride; triethylamine;
In
tetrahydrofuran; diethyl ether; toluene;
DOI:10.1016/j.tetlet.2012.11.079
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydroxide; potassium carbonate / ethanol; water / 12 h / 20 °C / Reflux
2.1: lithium aluminium tetrahydride / diethyl ether / 2.5 h / 0 - 20 °C
3.1: oxalyl dichloride / dimethyl sulfoxide; dichloromethane / 0.25 h / -70 °C
3.2: -70 - 20 °C
4.1: diethyl ether; tetrahydrofuran / 1 h / 0 °C
5.1: triethylamine; methanesulfonyl chloride / toluene / 0.25 h / 0 °C
5.2: 12 h / 0 - 20 °C
With
lithium aluminium tetrahydride; oxalyl dichloride; potassium carbonate; methanesulfonyl chloride; triethylamine; sodium hydroxide;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; dimethyl sulfoxide; toluene;
3.1: |Swern Oxidation / 3.2: |Swern Oxidation;
DOI:10.1016/j.tetlet.2012.11.079
