1‐(2‐(cyclohexylamino)pyrimidin‐4‐yl)‐2‐(naphthalen‐2‐yl)‐1H‐benzo[d]imidazol‐5‐ol

Base Information

Chemical Name:1‐(2‐(cyclohexylamino)pyrimidin‐4‐yl)‐2‐(naphthalen‐2‐yl)‐1H‐benzo[d]imidazol‐5‐ol
CAS No.:1428959-12-9
Molecular Formula:C₂₇H₂₅N₅O
Molecular Weight:435.528
Hs Code.:

Synonyms:1‐(2‐(cyclohexylamino)pyrimidin‐4‐yl)‐2‐(naphthalen‐2‐yl)‐1H‐benzo[d]imidazol‐5‐ol

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Chemical Property of 1‐(2‐(cyclohexylamino)pyrimidin‐4‐yl)‐2‐(naphthalen‐2‐yl)‐1H‐benzo[d]imidazol‐5‐ol

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Technology Process of 1‐(2‐(cyclohexylamino)pyrimidin‐4‐yl)‐2‐(naphthalen‐2‐yl)‐1H‐benzo[d]imidazol‐5‐ol

There total 8 articles about 1‐(2‐(cyclohexylamino)pyrimidin‐4‐yl)‐2‐(naphthalen‐2‐yl)‐1H‐benzo[d]imidazol‐5‐ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1428958-99-9
N-cyclohexyl-4-(5-methoxy-2-(naphthalen-2-yl)-1H-benzo[d]imidazol-1-yl)pyrimidin-2-amine

: 1428959-12-9
1‐(2‐(cyclohexylamino)pyrimidin‐4‐yl)‐2‐(naphthalen‐2‐yl)‐1H‐benzo[d]imidazol‐5‐ol

Guidance literature:: With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 3h;

Reference yield:

: 1428958-89-7
5-methoxy-1-(2-(methylthio)pyrimidin-4-yl)-2-(naphthalen-2-yl)-1H-benzo[d]imidazole

: 1428959-12-9
1‐(2‐(cyclohexylamino)pyrimidin‐4‐yl)‐2‐(naphthalen‐2‐yl)‐1H‐benzo[d]imidazol‐5‐ol

Guidance literature:: Multi-step reaction with 3 steps

1: Oxone / methanol; water / 1 h / 20 °C

2: tetrahydrofuran / 5 h / 60 °C

3: boron tribromide / dichloromethane / 3 h / -78 - 20 °C

With Oxone; boron tribromide; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

: 96-96-8
4-methoxy-2-nitroaniline

: 1428959-12-9
1‐(2‐(cyclohexylamino)pyrimidin‐4‐yl)‐2‐(naphthalen‐2‐yl)‐1H‐benzo[d]imidazol‐5‐ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 1 h / 0 °C

1.2: 2 h

2.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

3.1: sodium metabisulfite / N,N-dimethyl-formamide / 120 °C / Microwave irradiation

4.1: Oxone / methanol; water / 1 h / 20 °C

5.1: tetrahydrofuran / 5 h / 60 °C

6.1: boron tribromide / dichloromethane / 3 h / -78 - 20 °C

With sodium metabisulfite; Oxone; palladium 10% on activated carbon; hydrogen; boron tribromide; sodium hydride; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;