methyl 2-(5,6-dichloro-1H-indol-3-yl)acetate

Base Information

Chemical Name:methyl 2-(5,6-dichloro-1H-indol-3-yl)acetate
CAS No.:113537-13-6
Molecular Formula:C₁₁H₉Cl₂NO₂
Molecular Weight:258.104
Hs Code.:
DSSTox Substance ID:DTXSID70559757
Nikkaji Number:J650.691G
Wikidata:Q82442597
Mol file:113537-13-6.mol

Synonyms:113537-13-6;methyl 2-(5,6-dichloro-1H-indol-3-yl)acetate;methyl 5,6-dichloro-3-indoleacetate;SCHEMBL7128332;DTXSID70559757;Methyl (5,6-dichloro-1H-indol-3-yl)acetate;5,6-dichloroindole-3-acetic acid methyl ester;methyl2-(5,6-dichloro-1H-indol-3-yl)acetate

Suppliers and Price of methyl 2-(5,6-dichloro-1H-indol-3-yl)acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 7 raw suppliers

Chemical Property of methyl 2-(5,6-dichloro-1H-indol-3-yl)acetate

Chemical Property:

PSA：42.09000
LogP:3.19020
XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:257.0010339
Heavy Atom Count:16
Complexity:275

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)CC1=CNC2=CC(=C(C=C21)Cl)Cl

Technology Process of methyl 2-(5,6-dichloro-1H-indol-3-yl)acetate

There total 2 articles about methyl 2-(5,6-dichloro-1H-indol-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 98640-00-7
2-(5,6-dichloro-1H-indol-3-yl)acetic acid

: 113537-13-6
methyl 5,6-dichloroindole-3-acetate

Guidance literature:: In diethyl ether;
DOI:10.1271/bbb.65.270

Reference yield:

: 113537-13-6
methyl 5,6-dichloroindole-3-acetate

Guidance literature:

Reference yield:

: 113537-13-6
methyl 5,6-dichloroindole-3-acetate

: 338744-35-7
(+)-1-phenylethyl 2-(5,6-dichloro-3-indolyl)propionate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 90.5 percent / benzyltriethylammonium bromide; 30 percent NaOH / CH₂Cl₂ / 1 h / 0 °C

2.1: LDA / tetrahydrofuran / 1 h / -78 °C

2.2: 28.3 percent / tetrahydrofuran / 2 h / -78 °C

3.1: 93.1 percent / KOH / methanol; H₂O / 1 h / 70 °C

4.1: DCC; DMAP / CH₂Cl₂ / 5 h / 25 °C

With dmap; potassium hydroxide; sodium hydroxide; benzyltriethylammonium bromide; dicyclohexyl-carbodiimide; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1271/bbb.65.270