(4S,5S)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-phenyl-oxazolidin-2-one

Base Information

• Chemical Name: (4S,5S)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-phenyl-oxazolidin-2-one
• CAS No.: 131751-46-7
• Molecular Formula: C₁₆H₂₅NO₃Si
• Molecular Weight: 307.465

Synonyms:(4S,5S)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-phenyl-oxazolidin-2-one

Chemical Property of (4S,5S)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-phenyl-oxazolidin-2-one

Chemical Property:

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Technology Process of (4S,5S)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-phenyl-oxazolidin-2-one

There total 5 articles about (4S,5S)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-phenyl-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

[(1S,2S)-1-(tert-Butyl-dimethyl-silanyloxymethyl)-2-hydroxy-2-phenyl-ethyl]-carbamic acid benzyl ester (131751-41-2) → (4S,5S)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-phenyl-oxazolidin-2-one (131751-46-7)

Guidance literature:

With sodium methylate; In methanol;

DOI:10.1016/S0040-4039(00)98043-2

Reference yield: 70.0%

bis(trichloromethyl) carbonate (32315-10-9) + (1S,2S)-1-phenyl-amino-3-O-tertbutyldimethylsilyloxy-1-propanol (131472-79-2) → (4S,5S)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-phenyl-oxazolidin-2-one (131751-46-7)

Guidance literature:

In tetrahydrofuran;

DOI:10.1021/jo980951j

Reference yield: 70.0%

1,1'-carbonyldiimidazole (530-62-1) + (1S,2S)-1-phenyl-amino-3-O-tertbutyldimethylsilyloxy-1-propanol (131472-79-2) → (4S,5S)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-phenyl-oxazolidin-2-one (131751-46-7)

Guidance literature:

In tetrahydrofuran;

DOI:10.1021/jo980951j

upstream raw materials:

[(1S,2S)-1-(tert-Butyl-dimethyl-silanyloxymethyl)-2-hydroxy-2-phenyl-ethyl]-carbamic acid benzyl ester

bis(trichloromethyl) carbonate

(1S,2S)-1-phenyl-amino-3-O-tertbutyldimethylsilyloxy-1-propanol

1,1'-carbonyldiimidazole

Downstream raw materials:

(4S,5S)-4-hydroxymethyl-5-phenyloxazolidin-2-one

(1S,2S)-2-amino-3-morpholino-1-phenyl-1-propanol

(4S,5S)-4-Morpholin-4-ylmethyl-5-phenyl-oxazolidin-2-one

L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol

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