Technology Process of (8E)-1-((1R)-1-{[(4-methoxyphenyl)methoxy]methyl}propyl)(3S,6S,1R,4R,5R)-3-acetyloxy-5-methoxy-4,6-dimethyldec-8-enyl acetate
There total 16 articles about (8E)-1-((1R)-1-{[(4-methoxyphenyl)methoxy]methyl}propyl)(3S,6S,1R,4R,5R)-3-acetyloxy-5-methoxy-4,6-dimethyldec-8-enyl acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap; triethylamine;
In
dichloromethane;
at 20 ℃;
for 14h;
DOI:10.1021/ol015531m
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: KH / various solvents / 5 h / -15 - 20 °C
2.1: 0.85 g / OsO4; NaIO4; NMO / tetrahydrofuran; H2O; 2-methyl-propan-2-ol / 5 h / 20 °C
3.1: LiHMDS / tetrahydrofuran; hexane / 0.25 h / -78 °C
3.2: tetrahydrofuran; hexane / 15 h / -78 °C
4.1: 398 mg / BF3*Et2O / CH2Cl2 / 1 h / -90 °C
5.1: 76 mg / SmI2 / tetrahydrofuran; methanol / 14 h / -16 °C
6.1: 97 percent / NEt3; DMAP / CH2Cl2 / 14 h / 20 °C
With
dmap; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; samarium diiodide; boron trifluoride diethyl etherate; potassium hydride; triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; hexane; dichloromethane; various solvents; water; tert-butyl alcohol;
DOI:10.1021/ol015531m
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: KH / tetrahydrofuran / 0.5 h / -5 °C
1.2: 92 percent / tetrahydrofuran / 2.5 h / 20 °C
2.1: 9-BBN / tetrahydrofuran / 6 h / sonication
2.2: 88 percent / H2O2 / methanol; tetrahydrofuran; various solvent(s)
3.1: TPAP; NMO; 4 Angstroem molecular sieves / CH2Cl2 / 1.5 h / 0 °C
4.1: 1.6 g / PPh3 / CH2Cl2 / 0.5 h / -78 °C
5.1: n-BuLi / tetrahydrofuran; various solvent(s) / 1 h / -78 °C
5.2: 99 percent / DMPU / tetrahydrofuran; various solvent(s) / 1 h
6.1: 84 percent / Li; NH3 / tetrahydrofuran / 3.33 h / -78 - -40 °C
7.1: TPAP; NMO; 4 Angstroem molecular sieves / CH2Cl2 / 0.5 h / 0 °C
8.1: 398 mg / BF3*Et2O / CH2Cl2 / 1 h / -90 °C
9.1: 76 mg / SmI2 / tetrahydrofuran; methanol / 14 h / -16 °C
10.1: 97 percent / NEt3; DMAP / CH2Cl2 / 14 h / 20 °C
With
dmap; 9-borabicyclo[3.3.1]nonane dimer; n-butyllithium; N-methyl-2-indolinone; samarium diiodide; tetrapropylammonium perruthennate; 4 A molecular sieve; boron trifluoride diethyl etherate; ammonia; lithium; potassium hydride; triethylamine; triphenylphosphine;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ol015531m
