4-{[5-(2,4-Dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenylcarbamoyl]-methyl}-benzoic acid methyl ester

Base Information

Chemical Name:4-{[5-(2,4-Dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenylcarbamoyl]-methyl}-benzoic acid methyl ester
CAS No.:1027915-18-9
Molecular Formula:C₂₀H₁₈N₂O₆S
Molecular Weight:414.439
Hs Code.:

Synonyms:4-{[5-(2,4-Dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenylcarbamoyl]-methyl}-benzoic acid methyl ester

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Chemical Property of 4-{[5-(2,4-Dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenylcarbamoyl]-methyl}-benzoic acid methyl ester

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Technology Process of 4-{[5-(2,4-Dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenylcarbamoyl]-methyl}-benzoic acid methyl ester

There total 5 articles about 4-{[5-(2,4-Dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenylcarbamoyl]-methyl}-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 621-44-3
3-nitro-L-tyrosine

: 1027915-18-9
4-{[5-(2,4-Dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenylcarbamoyl]-methyl}-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: aq. NaNO₂, KBr, aq. 3 N H₂SO₄ / 0.17 h

2: AcONa / ethanol / 3 h / Heating

3: aq. HCl / 2-methoxy-ethanol / 4 h / Heating

4: 96 percent / H₂ / 10percent Pd/C / tetrahydrofuran; methanol / 8 h / 760 Torr

5: PhNMe₂ / tetrahydrofuran; 1,2-dimethoxy-ethane

With hydrogenchloride; sulfuric acid; hydrogen; sodium acetate; N,N-dimethyl-aniline; potassium bromide; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; 2-methoxy-ethanol;
DOI:10.1248/cpb.45.1984

Reference yield:

: 118383-65-6
2-bromo-3-(4-hydroxy-3-nitrophenyl)propionic acid

: 1027915-18-9
4-{[5-(2,4-Dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenylcarbamoyl]-methyl}-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: AcONa / ethanol / 3 h / Heating

2: aq. HCl / 2-methoxy-ethanol / 4 h / Heating

3: 96 percent / H₂ / 10percent Pd/C / tetrahydrofuran; methanol / 8 h / 760 Torr

4: PhNMe₂ / tetrahydrofuran; 1,2-dimethoxy-ethane

With hydrogenchloride; hydrogen; sodium acetate; N,N-dimethyl-aniline; palladium on activated charcoal; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; 2-methoxy-ethanol;
DOI:10.1248/cpb.45.1984

Reference yield:

: 118383-66-7
5-(4-hydroxy-3-nitrobenzyl)-2-imino-4-oxothiazolidine

: 1027915-18-9
4-{[5-(2,4-Dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenylcarbamoyl]-methyl}-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: aq. HCl / 2-methoxy-ethanol / 4 h / Heating

2: 96 percent / H₂ / 10percent Pd/C / tetrahydrofuran; methanol / 8 h / 760 Torr

3: PhNMe₂ / tetrahydrofuran; 1,2-dimethoxy-ethane

With hydrogenchloride; hydrogen; N,N-dimethyl-aniline; palladium on activated charcoal; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; 2-methoxy-ethanol;
DOI:10.1248/cpb.45.1984