4-[(4-benzyloxy-phenyl)-(3-methyl-but-2-enyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-[(4-benzyloxy-phenyl)-(3-methyl-but-2-enyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester
• CAS No.: 241499-29-6
• Molecular Formula: C₂₈H₃₈N₂O₃
• Molecular Weight: 450.621

Synonyms:4-[(4-benzyloxy-phenyl)-(3-methyl-but-2-enyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property of 4-[(4-benzyloxy-phenyl)-(3-methyl-but-2-enyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

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Technology Process of 4-[(4-benzyloxy-phenyl)-(3-methyl-but-2-enyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester

There total 6 articles about 4-[(4-benzyloxy-phenyl)-(3-methyl-but-2-enyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

prenyl bromide (870-63-3) + 4-(4-benzyloxy-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester (220741-33-3) → 4-[(4-benzyloxy-phenyl)-(3-methyl-but-2-enyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester (241499-29-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 40 ℃; for 18h;

DOI:10.1021/jm9902739

Reference yield:

4-benzyloxyaniline hydrochloride (51388-20-6) → 4-[(4-benzyloxy-phenyl)-(3-methyl-but-2-enyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester (241499-29-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / NaBH(OAc)3 / CH₂Cl₂ / 18 h / 20 °C

2: 87 percent / N,N-diisopropylethylamine / tetrahydrofuran / 18 h / 40 °C

With sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; 1: reductive amination / 2: Alkylation;

DOI:10.1021/jm9902739

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → 4-[(4-benzyloxy-phenyl)-(3-methyl-but-2-enyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester (241499-29-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / NaBH(OAc)3 / CH₂Cl₂ / 18 h / 20 °C

2: 87 percent / N,N-diisopropylethylamine / tetrahydrofuran / 18 h / 40 °C

With sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; 1: reductive amination / 2: Alkylation;

DOI:10.1021/jm9902739

upstream raw materials:

prenyl bromide

4-(4-benzyloxy-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester

p-benzyloxyaniline

N-tert-butyloxycarbonylpiperidin-4-one

Downstream raw materials:

(4-benzyloxy-phenyl)-(3-methyl-but-2-enyl)-piperidin-4-yl-amine

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