8-(benzyloxy)-5-{(1R)-1-hydroxy-2-[({4-(hydroxymethyl)-1-[2-(2-phenylethoxy)ethyl]piperidin-4-yl}methyl)amino]ethyl}quinolin-2(1H)-one

Base Information

Chemical Name:8-(benzyloxy)-5-{(1R)-1-hydroxy-2-[({4-(hydroxymethyl)-1-[2-(2-phenylethoxy)ethyl]piperidin-4-yl}methyl)amino]ethyl}quinolin-2(1H)-one
CAS No.:948895-16-7
Molecular Formula:C₃₅H₄₃N₃O₅
Molecular Weight:585.744
Hs Code.:

Synonyms:8-(benzyloxy)-5-{(1R)-1-hydroxy-2-[({4-(hydroxymethyl)-1-[2-(2-phenylethoxy)ethyl]piperidin-4-yl}methyl)amino]ethyl}quinolin-2(1H)-one

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Chemical Property of 8-(benzyloxy)-5-{(1R)-1-hydroxy-2-[({4-(hydroxymethyl)-1-[2-(2-phenylethoxy)ethyl]piperidin-4-yl}methyl)amino]ethyl}quinolin-2(1H)-one

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Technology Process of 8-(benzyloxy)-5-{(1R)-1-hydroxy-2-[({4-(hydroxymethyl)-1-[2-(2-phenylethoxy)ethyl]piperidin-4-yl}methyl)amino]ethyl}quinolin-2(1H)-one

There total 10 articles about 8-(benzyloxy)-5-{(1R)-1-hydroxy-2-[({4-(hydroxymethyl)-1-[2-(2-phenylethoxy)ethyl]piperidin-4-yl}methyl)amino]ethyl}quinolin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 8-(benzyloxy)-5-{(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-[({4-(hydroxymethyl)-1-[2-(2-phenylethoxy)ethyl]piperidin-4-yl}methyl)amino]ethyl}quinolin-2(1H)-one di(trifluoroacetate)

: 948895-16-7
8-(benzyloxy)-5-{(1R)-1-hydroxy-2-[({4-(hydroxymethyl)-1-[2-(2-phenylethoxy)ethyl]piperidin-4-yl}methyl)amino]ethyl}quinolin-2(1H)-one

Guidance literature:: With triethylamine tris(hydrogen fluoride); In tetrahydrofuran; at 20 ℃; for 2.5h;

Reference yield:

: 724790-59-4
4-methyl-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-methyl ester

: 948895-16-7
8-(benzyloxy)-5-{(1R)-1-hydroxy-2-[({4-(hydroxymethyl)-1-[2-(2-phenylethoxy)ethyl]piperidin-4-yl}methyl)amino]ethyl}quinolin-2(1H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.75 h / -78 - -72 °C

1.2: -78 - 20 °C

2.1: sodium azide / dimethyl sulfoxide / 4 h / 95 °C

3.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C

6.1: sodium hydrogencarbonate / potassium iodide / dimethyl sulfoxide / 12 h / 100 °C

7.1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 2.5 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; n-butyllithium; sodium azide; sodium hydrogencarbonate; triethylamine tris(hydrogen fluoride); N-ethyl-N,N-diisopropylamine; potassium iodide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 948895-09-8
1-tert-butyl 4-methyl 4-(azidomethyl)piperidine-1,4-dicarboxylate

: 948895-16-7
8-(benzyloxy)-5-{(1R)-1-hydroxy-2-[({4-(hydroxymethyl)-1-[2-(2-phenylethoxy)ethyl]piperidin-4-yl}methyl)amino]ethyl}quinolin-2(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C

4: sodium hydrogencarbonate / potassium iodide / dimethyl sulfoxide / 12 h / 100 °C

5: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 2.5 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; sodium hydrogencarbonate; triethylamine tris(hydrogen fluoride); N-ethyl-N,N-diisopropylamine; potassium iodide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; dimethyl sulfoxide;