Technology Process of 2-fluoro-N-(2-formyl-7-methyl-1H-indol-6-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide
There total 11 articles about 2-fluoro-N-(2-formyl-7-methyl-1H-indol-6-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: hydrogenchloride; sodium nitrite / acetonitrile; water / 0.5 h / -10 - -5 °C
1.2: 0.17 h / -6 - 2 °C
1.3: 1 h / 0 °C
2.1: methanesulfonic acid; Eaton′s Reagent / toluene / 0.33 h / 80 °C
3.1: hydrogen / palladium-on-charcoal / ethanol; tetrahydrofuran / 20 h / 20 °C / 760.05 Torr
4.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 2 h / 20 °C
4.2: 20 °C
5.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C
6.1: manganese(IV) oxide / tetrahydrofuran / 40 °C
With
hydrogenchloride; manganese(IV) oxide; lithium aluminium tetrahydride; oxalyl dichloride; methanesulfonic acid; Eaton′s Reagent; hydrogen; sodium nitrite;
palladium-on-charcoal; N,N-dimethyl-formamide;
In
tetrahydrofuran; ethanol; water; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 2 h / 20 °C
1.2: 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C
3.1: manganese(IV) oxide / tetrahydrofuran / 40 °C
With
manganese(IV) oxide; lithium aluminium tetrahydride; oxalyl dichloride;
N,N-dimethyl-formamide;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogen / palladium-on-charcoal / ethanol; tetrahydrofuran / 20 h / 20 °C / 760.05 Torr
2.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 2 h / 20 °C
2.2: 20 °C
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C
4.1: manganese(IV) oxide / tetrahydrofuran / 40 °C
With
manganese(IV) oxide; lithium aluminium tetrahydride; oxalyl dichloride; hydrogen;
palladium-on-charcoal; N,N-dimethyl-formamide;
In
tetrahydrofuran; ethanol;