4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-(5-methyl-1,2,4-thiadiazol-3-ylamino)thiazole-5-carbonitrile

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Chemical Name:4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-(5-methyl-1,2,4-thiadiazol-3-ylamino)thiazole-5-carbonitrile
CAS No.:1355335-75-9
Molecular Formula:C₁₈H₁₅N₇OS₂
Molecular Weight:409.495
Hs Code.:

Synonyms:4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-(5-methyl-1,2,4-thiadiazol-3-ylamino)thiazole-5-carbonitrile

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Chemical Property of 4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-(5-methyl-1,2,4-thiadiazol-3-ylamino)thiazole-5-carbonitrile

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Technology Process of 4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-(5-methyl-1,2,4-thiadiazol-3-ylamino)thiazole-5-carbonitrile

There total 6 articles about 4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-(5-methyl-1,2,4-thiadiazol-3-ylamino)thiazole-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 27182-55-4
5-methyl-1,2,4-thiadiazol-3-amine

: 1262849-20-6
2-bromo-4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)thiazole-5-carbonitrile

: 1355335-75-9
4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-(5-methyl-1,2,4-thiadiazol-3-ylamino)thiazole-5-carbonitrile

Guidance literature:: With potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; Inert atmosphere; Reflux;

Reference yield:

: 1105039-65-3
3-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-3-oxo-propanenitrile

: 1355335-75-9
4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-(5-methyl-1,2,4-thiadiazol-3-ylamino)thiazole-5-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: copper(ll) bromide / ethyl acetate; chloroform; tetrahydrofuran / 3 h / Inert atmosphere; Reflux

2: ethanol / 2 h / Inert atmosphere; Reflux

3: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 1.5 h / 20 - 80 °C / Inert atmosphere

4: potassium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / Inert atmosphere; Reflux

With tert.-butylnitrite; potassium carbonate; copper(ll) bromide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; ethanol; chloroform; ethyl acetate; acetonitrile;

Reference yield:

: 1-(4-methoxybenzyl)-1H-pyrazole-4-carboxylic acid ethyl ester

: 1355335-75-9
4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-(5-methyl-1,2,4-thiadiazol-3-ylamino)thiazole-5-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere

1.2: 2 h / -78 - 20 °C

2.1: copper(ll) bromide / ethyl acetate; chloroform; tetrahydrofuran / 3 h / Inert atmosphere; Reflux

3.1: ethanol / 2 h / Inert atmosphere; Reflux

4.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 1.5 h / 20 - 80 °C / Inert atmosphere

5.1: potassium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / Inert atmosphere; Reflux

With n-butyllithium; tert.-butylnitrite; potassium carbonate; copper(ll) bromide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; ethanol; chloroform; ethyl acetate; acetonitrile;