(S)-2-({(S)-2-[(2R,3R)-3-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-2-methyl-butyryloxy]-3-methyl-butyryl}-methyl-amino)-3-methyl-butyric acid (S)-1-benzyloxycarbonyl-2-phenyl-ethyl ester

Base Information

• Chemical Name: (S)-2-({(S)-2-[(2R,3R)-3-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-2-methyl-butyryloxy]-3-methyl-butyryl}-methyl-amino)-3-methyl-butyric acid (S)-1-benzyloxycarbonyl-2-phenyl-ethyl ester
• CAS No.: 155096-19-8
• Molecular Formula: C₄₆H₆₁N₃O₁₀
• Molecular Weight: 816.004

Synonyms:(S)-2-({(S)-2-[(2R,3R)-3-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-2-methyl-butyryloxy]-3-methyl-butyryl}-methyl-amino)-3-methyl-butyric acid (S)-1-benzyloxycarbonyl-2-phenyl-ethyl ester

Chemical Property of (S)-2-({(S)-2-[(2R,3R)-3-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-2-methyl-butyryloxy]-3-methyl-butyryl}-methyl-amino)-3-methyl-butyric acid (S)-1-benzyloxycarbonyl-2-phenyl-ethyl ester

Chemical Property:

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Technology Process of (S)-2-({(S)-2-[(2R,3R)-3-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-2-methyl-butyryloxy]-3-methyl-butyryl}-methyl-amino)-3-methyl-butyric acid (S)-1-benzyloxycarbonyl-2-phenyl-ethyl ester

There total 11 articles about (S)-2-({(S)-2-[(2R,3R)-3-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-2-methyl-butyryloxy]-3-methyl-butyryl}-methyl-amino)-3-methyl-butyric acid (S)-1-benzyloxycarbonyl-2-phenyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Cbz-L-Isoleucine (3160-59-6) + (S)-2-{[(S)-2-((2R,3R)-3-Amino-2-methyl-butyryloxy)-3-methyl-butyryl]-methyl-amino}-3-methyl-butyric acid (S)-1-benzyloxycarbonyl-2-phenyl-ethyl ester → (S)-2-({(S)-2-[(2R,3R)-3-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-2-methyl-butyryloxy]-3-methyl-butyryl}-methyl-amino)-3-methyl-butyric acid (S)-1-benzyloxycarbonyl-2-phenyl-ethyl ester (155096-19-8)

Guidance literature:

With diethyl cyanophosphonate; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; Yield given;

DOI:10.1016/S0040-4039(00)61356-4

Reference yield:

t-Boc-L-valine (13734-41-3) → (S)-2-({(S)-2-[(2R,3R)-3-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-2-methyl-butyryloxy]-3-methyl-butyryl}-methyl-amino)-3-methyl-butyric acid (S)-1-benzyloxycarbonyl-2-phenyl-ethyl ester (155096-19-8)

Guidance literature:

Multi-step reaction with 8 steps

1: 88 percent / DCC, DMAP / CH₂Cl₂ / 0 - 20 °C

2: CF₃COOH / CH₂Cl₂ / 0 °C

3: diethyl phosphorocyanidate, Et₃N / dimethylformamide / 0 - 20 °C

4: 75 percent / NaH / dimethylformamide / 0 °C

5: 98 percent / 12percent HF / H₂O; acetonitrile / Ambient temperature

6: 98 percent / DCC, DMAP, 10-camphorsulfonic acid / CH₂Cl₂ / 0 - 20 °C

7: CF₃COOH / CH₂Cl₂ / 0 °C

8: diethyl phosphorocyanidate, Et₃N / dimethylformamide / 0 - 20 °C

With dmap; diethyl cyanophosphonate; (1S)-10-camphorsulfonic acid; hydrogen fluoride; sodium hydride; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0040-4039(00)61356-4

Reference yield:

benzyl-(S)-(-)-2-hydroxy-3-phenylpropionate (7622-21-1) → (S)-2-({(S)-2-[(2R,3R)-3-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-2-methyl-butyryloxy]-3-methyl-butyryl}-methyl-amino)-3-methyl-butyric acid (S)-1-benzyloxycarbonyl-2-phenyl-ethyl ester (155096-19-8)

Guidance literature:

Multi-step reaction with 8 steps

1: 88 percent / DCC, DMAP / CH₂Cl₂ / 0 - 20 °C

2: CF₃COOH / CH₂Cl₂ / 0 °C

3: diethyl phosphorocyanidate, Et₃N / dimethylformamide / 0 - 20 °C

4: 75 percent / NaH / dimethylformamide / 0 °C

5: 98 percent / 12percent HF / H₂O; acetonitrile / Ambient temperature

6: 98 percent / DCC, DMAP, 10-camphorsulfonic acid / CH₂Cl₂ / 0 - 20 °C

7: CF₃COOH / CH₂Cl₂ / 0 °C

8: diethyl phosphorocyanidate, Et₃N / dimethylformamide / 0 - 20 °C

With dmap; diethyl cyanophosphonate; (1S)-10-camphorsulfonic acid; hydrogen fluoride; sodium hydride; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0040-4039(00)61356-4

upstream raw materials:

N-Cbz-L-Isoleucine

t-Boc-L-valine

benzyl-(S)-(-)-2-hydroxy-3-phenylpropionate

methyl RR-2-methyl-3-(t-butyloxycarbonylamino)-butyrate

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