Technology Process of 3,4-bis-(4-methoxyphenyl)pyrrole-2,5-dicarboxylic acid monoethyl ester
There total 5 articles about 3,4-bis-(4-methoxyphenyl)pyrrole-2,5-dicarboxylic acid monoethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium chlorite monohydrate;
In
aq. phosphate buffer; dimethyl sulfoxide;
at 60 ℃;
for 2h;
Sealed tube;
Microwave irradiation;
DOI:10.1016/j.tet.2014.02.091
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: water; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium(0) / toluene; ethanol / 2 h / 110 °C / Sealed tube; Microwave irradiation
2.1: potassium hydroxide / N,N-dimethyl-formamide / 0.25 h
2.2: 20 °C
3.1: 1,4-diaza-bicyclo[2.2.2]octane; water; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / toluene; ethanol / 2 h / 110 °C / Sealed tube; Microwave irradiation
4.1: sodium chlorite monohydrate / dimethyl sulfoxide; aq. phosphate buffer / 2 h / 60 °C / Sealed tube; Microwave irradiation
With
1,4-diaza-bicyclo[2.2.2]octane; tetrakis(triphenylphosphine) palladium(0); dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium chlorite monohydrate; water; N-ethyl-N,N-diisopropylamine; potassium hydroxide;
In
aq. phosphate buffer; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
1.1: |Suzuki-Miyaura Coupling / 3.1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.tet.2014.02.091
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium hydroxide / N,N-dimethyl-formamide / 0.25 h
1.2: 20 °C
2.1: 1,4-diaza-bicyclo[2.2.2]octane; water; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / toluene; ethanol / 2 h / 110 °C / Sealed tube; Microwave irradiation
3.1: sodium chlorite monohydrate / dimethyl sulfoxide; aq. phosphate buffer / 2 h / 60 °C / Sealed tube; Microwave irradiation
With
1,4-diaza-bicyclo[2.2.2]octane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium chlorite monohydrate; water; potassium hydroxide;
In
aq. phosphate buffer; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
2.1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.tet.2014.02.091
