(E)-(4S,6S,7R)-7-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-7-methoxy-6-methyl-hept-2-en-4-ol

Base Information

Chemical Name:(E)-(4S,6S,7R)-7-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-7-methoxy-6-methyl-hept-2-en-4-ol
CAS No.:122911-40-4
Molecular Formula:C₂₃H₃₃NO₄
Molecular Weight:387.519
Hs Code.:

Synonyms:(E)-(4S,6S,7R)-7-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-7-methoxy-6-methyl-hept-2-en-4-ol

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Chemical Property of (E)-(4S,6S,7R)-7-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-7-methoxy-6-methyl-hept-2-en-4-ol

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Technology Process of (E)-(4S,6S,7R)-7-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-7-methoxy-6-methyl-hept-2-en-4-ol

There total 4 articles about (E)-(4S,6S,7R)-7-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-7-methoxy-6-methyl-hept-2-en-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 122911-39-1
1-{3-[(E)-(1R,2S,4S)-4-(tert-Butyl-dimethyl-silanyloxy)-1-methoxy-2-methyl-hept-5-enyl]-2,5-dimethoxy-phenyl}-2,5-dimethyl-1H-pyrrole

: 122911-40-4
(E)-(4S,6S,7R)-7-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-7-methoxy-6-methyl-hept-2-en-4-ol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 16h; Ambient temperature;
DOI:10.1039/P19900000047

Reference yield:

: 128836-50-0
(2S,4S,5R)-5-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-2-hydroxy-5-methoxy-4-methyl-pentanoic acid methyl ester

: 122911-40-4
(E)-(4S,6S,7R)-7-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-7-methoxy-6-methyl-hept-2-en-4-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 0 °C

2: diisobutylaluminium hydride / toluene / 2 h / -80 °C

3: CrCl₂ / tetrahydrofuran / 2.5 h / 25 °C

4: 96 percent / Bu₄NF / tetrahydrofuran / 16 h / 25 °C

With 2,6-dimethylpyridine; chromium dichloride; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 122911-38-0
(2S,4S,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-5-[3-(2,5-dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-5-methoxy-4-methyl-pentanal

: 122911-40-4
(E)-(4S,6S,7R)-7-[3-(2,5-Dimethyl-pyrrol-1-yl)-2,5-dimethoxy-phenyl]-7-methoxy-6-methyl-hept-2-en-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1: CrCl₂ / tetrahydrofuran / 2.5 h / 25 °C

2: 96 percent / Bu₄NF / tetrahydrofuran / 16 h / 25 °C

With chromium dichloride; tetrabutyl ammonium fluoride; In tetrahydrofuran;