[4-(4-methoxy-phenoxy)-2-phenylethynyl-pyrimidin-5-yl]-pyrrolidin-2-(S)-ylmethyl-amine hydrochloride

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Chemical Name:[4-(4-methoxy-phenoxy)-2-phenylethynyl-pyrimidin-5-yl]-pyrrolidin-2-(S)-ylmethyl-amine hydrochloride
CAS No.:1297929-77-1
Molecular Formula:C₂₄H₂₄N₄O₂*ClH
Molecular Weight:436.941
Hs Code.:

Synonyms:[4-(4-methoxy-phenoxy)-2-phenylethynyl-pyrimidin-5-yl]-pyrrolidin-2-(S)-ylmethyl-amine hydrochloride

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Chemical Property of [4-(4-methoxy-phenoxy)-2-phenylethynyl-pyrimidin-5-yl]-pyrrolidin-2-(S)-ylmethyl-amine hydrochloride

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Technology Process of [4-(4-methoxy-phenoxy)-2-phenylethynyl-pyrimidin-5-yl]-pyrrolidin-2-(S)-ylmethyl-amine hydrochloride

There total 7 articles about [4-(4-methoxy-phenoxy)-2-phenylethynyl-pyrimidin-5-yl]-pyrrolidin-2-(S)-ylmethyl-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1297931-13-5
2-(S)-{[4-(4-methoxy-phenoxy)-2-phenylethynyl-pyrimidin-5-ylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1297929-77-1
[4-(4-methoxy-phenoxy)-2-phenylethynyl-pyrimidin-5-yl]-pyrrolidin-2-(S)-ylmethyl-amine hydrochloride

Guidance literature:: 2-(S)-{[4-(4-methoxy-phenoxy)-2-phenylethynyl-pyrimidin-5-ylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 20h;

With sodium hydroxide; In dichloromethane; water; pH=12;

With hydrogenchloride; In diethyl ether; dichloromethane; at 20 ℃; for 20h;

Reference yield:

: 1297930-95-0
{2-[2,4-Bis-(4-methoxy-phenoxy)-pyrimidin-5-ylamino]ethyl}-carbamic acid tert-butyl ester

: 1297929-77-1
[4-(4-methoxy-phenoxy)-2-phenylethynyl-pyrimidin-5-yl]-pyrrolidin-2-(S)-ylmethyl-amine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 20 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 72 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 150 °C / Microwave irradiation

4.1: trifluoroacetic acid / dichloromethane / 20 h / 20 °C

4.2: pH 12

4.3: 20 h / 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; acetonitrile;

Reference yield:

: 1297931-01-1
2-Chloro-4-(4-methoxy-phenoxy)-pyrimidin-5-ylamine

: 1297929-77-1
[4-(4-methoxy-phenoxy)-2-phenylethynyl-pyrimidin-5-yl]-pyrrolidin-2-(S)-ylmethyl-amine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 16 h / 20 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 150 °C / Microwave irradiation

3.1: trifluoroacetic acid / dichloromethane / 20 h / 20 °C

3.2: pH 12

3.3: 20 h / 20 °C

With sodium tris(acetoxy)borohydride; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; 1,2-dichloro-ethane;