(E)-4-[2-(4-Methoxy-benzyl)-1,4-dioxo-hexahydro-pyrrolo[1,2-a]pyrazin-8a-yl]-2-methyl-but-2-enal

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Chemical Name:(E)-4-[2-(4-Methoxy-benzyl)-1,4-dioxo-hexahydro-pyrrolo[1,2-a]pyrazin-8a-yl]-2-methyl-but-2-enal
CAS No.:109164-84-3
Molecular Formula:C₂₀H₂₄N₂O₄
Molecular Weight:356.422
Hs Code.:

Synonyms:(E)-4-[2-(4-Methoxy-benzyl)-1,4-dioxo-hexahydro-pyrrolo[1,2-a]pyrazin-8a-yl]-2-methyl-but-2-enal

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Chemical Property of (E)-4-[2-(4-Methoxy-benzyl)-1,4-dioxo-hexahydro-pyrrolo[1,2-a]pyrazin-8a-yl]-2-methyl-but-2-enal

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Technology Process of (E)-4-[2-(4-Methoxy-benzyl)-1,4-dioxo-hexahydro-pyrrolo[1,2-a]pyrazin-8a-yl]-2-methyl-but-2-enal

There total 9 articles about (E)-4-[2-(4-Methoxy-benzyl)-1,4-dioxo-hexahydro-pyrrolo[1,2-a]pyrazin-8a-yl]-2-methyl-but-2-enal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 24720-64-7
2-(triphenylphosphoranylidene)propionaldehyde

: 109164-81-0
[2-(4-Methoxy-benzyl)-1,4-dioxo-hexahydro-pyrrolo[1,2-a]pyrazin-8a-yl]-acetaldehyde

: 109164-84-3
(E)-4-[2-(4-Methoxy-benzyl)-1,4-dioxo-hexahydro-pyrrolo[1,2-a]pyrazin-8a-yl]-2-methyl-but-2-enal

Guidance literature:: In 1,2-dichloro-benzene; at 115 ℃; for 3h;
DOI:10.1016/S0040-4039(00)84854-6

Reference yield:

: 79074-03-6
2-(benzyloxycarbonylamino)-4-hydroxybutanoic acid

: 109164-84-3
(E)-4-[2-(4-Methoxy-benzyl)-1,4-dioxo-hexahydro-pyrrolo[1,2-a]pyrazin-8a-yl]-2-methyl-but-2-enal

Guidance literature:: Multi-step reaction with 8 steps

1: Et₃N / dimethylformamide / 0 °C

2: DCC / tetrahydrofuran / 25 °C

3: H₂ / 10percent Pd-C / ethanol / 760 Torr

4: KOtBu / dimethylformamide / 0 °C

5: NaH / dimethylformamide / 25 °C

6: 93 percent / HF-pyridine / tetrahydrofuran / 25 °C

7: 82 percent / ClCOCOCl,Et₃N / dimethylsulfoxide; CH₂Cl₂

8: 96 percent / 1,2-dichloro-benzene / 3 h / 115 °C

With oxalyl dichloride; potassium tert-butylate; hydrogen; sodium hydride; pyridine hydrogenfluoride; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; 1,2-dichloro-benzene;
DOI:10.1016/S0040-4039(00)84854-6

Reference yield:

: 60857-16-1
N-(4-methoxybenzyl)glycine ethyl ester

: 109164-84-3
(E)-4-[2-(4-Methoxy-benzyl)-1,4-dioxo-hexahydro-pyrrolo[1,2-a]pyrazin-8a-yl]-2-methyl-but-2-enal

Guidance literature:: Multi-step reaction with 7 steps

1: DCC / tetrahydrofuran / 25 °C

2: H₂ / 10percent Pd-C / ethanol / 760 Torr

3: KOtBu / dimethylformamide / 0 °C

4: NaH / dimethylformamide / 25 °C

5: 93 percent / HF-pyridine / tetrahydrofuran / 25 °C

6: 82 percent / ClCOCOCl,Et₃N / dimethylsulfoxide; CH₂Cl₂

7: 96 percent / 1,2-dichloro-benzene / 3 h / 115 °C

With oxalyl dichloride; potassium tert-butylate; hydrogen; sodium hydride; pyridine hydrogenfluoride; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; 1,2-dichloro-benzene;
DOI:10.1016/S0040-4039(00)84854-6