N-diethoxyphosphinoyl-3-chlorobenzaldimine

Base Information

• Chemical Name: N-diethoxyphosphinoyl-3-chlorobenzaldimine
• CAS No.: 252354-11-3
• Molecular Formula: C₁₁H₁₅ClNO₃P
• Molecular Weight: 275.672
• Mol file: 252354-11-3.mol

Synonyms:N-diethoxyphosphinoyl-3-chlorobenzaldimine

Chemical Property of N-diethoxyphosphinoyl-3-chlorobenzaldimine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-diethoxyphosphinoyl-3-chlorobenzaldimine

There total 1 articles about N-diethoxyphosphinoyl-3-chlorobenzaldimine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

Diethyl phosphoramidate (1068-21-9) + 3-chlorobenzaldehyde diethyl acetal (68578-52-9) → N-diethoxyphosphinoyl-3-chlorobenzaldimine (252354-11-3)

Guidance literature:

at 160 ℃; for 0.5h; Reduced pressure; Inert atmosphere;

DOI:10.1021/ol802569q

Reference yield: 84.0%

α-methoxycarbonyl-α-phenyl-γ-methylidene-δ-valerolactone (958000-84-5) + N-diethoxyphosphinoyl-3-chlorobenzaldimine (252354-11-3) → C24H29ClNO5P + C24H29ClNO5P

Guidance literature:

With 1,1'-bis(diphenylphosphino)ferrocene; PdCp(η3-C3H5); In toluene; at 20 ℃; for 24h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;

DOI:10.1021/ol802569q

Reference yield: 82.0%

methyl 2-nitro-propionate (62013-44-9,6118-50-9) + N-diethoxyphosphinoyl-3-chlorobenzaldimine (252354-11-3) → methyl (2S,3S)-3-((diethoxyphosphoryl)amino)-3-(3-chlorophenyl)-2-methyl-2-nitropropanoate (1430818-87-3)

Guidance literature:

With C₂₈H₂₆F₆N₄S; In toluene; at -20 ℃; for 17h; enantioselective reaction; Inert atmosphere;

DOI:10.1039/c3ob40335a

upstream raw materials:

Diethyl phosphoramidate

3-chlorobenzaldehyde diethyl acetal

Downstream raw materials:

methyl (2S,3S)-3-((diethoxyphosphoryl)amino)-3-(3-chlorophenyl)-2-methyl-2-nitropropanoate

methyl (2S,3S)-2-((3-chlorophenyl)((diethoxyphosphoryl)amino)methyl)-2-nitrobutanoate