<<4(5)R>-2-<1(R)-1-amino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazol-4(5)-oyl>-(S)-aspartyl-(S)-phenylalanine amide

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Chemical Name:<<4(5)R>-2-<1(R)-1-amino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazol-4(5)-oyl>-(S)-aspartyl-(S)-phenylalanine amide
CAS No.:169869-62-9
Molecular Formula:C₃₆H₄₇N₇O₇
Molecular Weight:689.812
Hs Code.:

Synonyms:<<4(5)R>-2-<1(R)-1-amino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazol-4(5)-oyl>-(S)-aspartyl-(S)-phenylalanine amide

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Chemical Property of <<4(5)R>-2-<1(R)-1-amino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazol-4(5)-oyl>-(S)-aspartyl-(S)-phenylalanine amide

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Technology Process of <<4(5)R>-2-<1(R)-1-amino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazol-4(5)-oyl>-(S)-aspartyl-(S)-phenylalanine amide

There total 14 articles about <<4(5)R>-2-<1(R)-1-amino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazol-4(5)-oyl>-(S)-aspartyl-(S)-phenylalanine amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 160637-58-1
<<4(5)R>-2-<1(R)-1-benzyloxycarbonylamino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazol-4(5)-oyl>-(S)-aspartyl-(S)-phenylalanine amide

: 169869-62-9
<<4(5)R>-2-<1(R)-1-amino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazol-4(5)-oyl>-(S)-aspartyl-(S)-phenylalanine amide

Guidance literature:: With hydrogen; palladium dihydroxide; In methanol; under 2585.7 Torr;
DOI:10.1016/0957-4166(94)80075-8

Reference yield:

: 327-56-0
D-norleucine

: 169869-62-9
<<4(5)R>-2-<1(R)-1-amino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazol-4(5)-oyl>-(S)-aspartyl-(S)-phenylalanine amide

Guidance literature:: Multi-step reaction with 10 steps

1: 95 percent / 1 M aq. NaOH / ethanol

2: 56 percent / CH₂Cl₂ / -20 °C

3: 1.) LiN(SiMe₃)2 / 1.) THF, from -78 to -65 deg C, 2.) THF

4: 75 percent / AcCl / 16 h / Heating

5: 1.) MeI / 1.) reflux, 16 h, 2.) MeOH, reflux, 16 h

6: aq. NaHCO₃ / tetrahydrofuran

7: 0.1 M aq. LiOH / tetrahydrofuran

8: DCC / ethyl acetate

9: Et₃N / ethyl acetate; dimethylformamide

10: 98 percent / H₂ / Pd(OH)2/C / methanol / 2585.7 Torr

With lithium hydroxide; sodium hydroxide; hydrogen; sodium hydrogencarbonate; triethylamine; acetyl chloride; dicyclohexyl-carbodiimide; lithium hexamethyldisilazane; methyl iodide; palladium dihydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/0957-4166(94)80075-8

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 169869-62-9
<<4(5)R>-2-<1(R)-1-amino-2-(3-indolyl)ethyl>-4(5)-butyl-1(3)-tert-butyloxycarbonyl-4,5-dihydroimidazol-4(5)-oyl>-(S)-aspartyl-(S)-phenylalanine amide

Guidance literature:: Multi-step reaction with 5 steps

1: aq. NaHCO₃ / tetrahydrofuran

2: 0.1 M aq. LiOH / tetrahydrofuran

3: DCC / ethyl acetate

4: Et₃N / ethyl acetate; dimethylformamide

5: 98 percent / H₂ / Pd(OH)2/C / methanol / 2585.7 Torr

With lithium hydroxide; hydrogen; sodium hydrogencarbonate; triethylamine; dicyclohexyl-carbodiimide; palladium dihydroxide; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/0957-4166(94)80075-8