(E)-2-fluoro-4-phenyl-2-penten-1-ol

Base Information

• Chemical Name: (E)-2-fluoro-4-phenyl-2-penten-1-ol
• CAS No.: 151222-56-9
• Molecular Formula: C₁₁H₁₃FO
• Molecular Weight: 180.222
• Mol file: 151222-56-9.mol

Synonyms:(E)-2-fluoro-4-phenyl-2-penten-1-ol

Chemical Property of (E)-2-fluoro-4-phenyl-2-penten-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-fluoro-4-phenyl-2-penten-1-ol

There total 1 articles about (E)-2-fluoro-4-phenyl-2-penten-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(E)-2-fluoro-4-phenyl-2-pentenoic acid methyl ester (101128-09-0) → (E)-2-fluoro-4-phenyl-2-penten-1-ol (151222-56-9)

Guidance literature:

With diisobutylaluminium hydride; In toluene; at -40 ℃; for 0.75h;

DOI:10.1021/jm00071a011

Reference yield:

(E)-2-fluoro-4-phenyl-2-penten-1-ol (151222-56-9) → (E)-2-Fluoro-4-phenyl-pent-2-enal

Guidance literature:

With manganese(IV) oxide; In dichloromethane; for 16h; Ambient temperature;

DOI:10.1021/jm00071a011

Reference yield:

(E)-2-fluoro-4-phenyl-2-penten-1-ol (151222-56-9) → 3-fluoro-1-methylnaphthalene (59079-88-8)

Guidance literature:

Multi-step reaction with 2 steps

1: MnO₂ / CH₂Cl₂ / 16 h / Ambient temperature

2: PPA / 0.33 h / 65 °C

With manganese(IV) oxide; In dichloromethane;

DOI:10.1021/jm00071a011

upstream raw materials:

(E)-2-fluoro-4-phenyl-2-pentenoic acid methyl ester

Downstream raw materials:

3-fluoro-1-methylnaphthalene