N-[1-(1-(4-(imidazo(2,1-b)benzothiazol-2-yl)phenyl-1H-1,2,3-triazol-4-yl)-2-phenylethyl)]-2-[3,5-bis(trifluoromethyl)phenyl]acetamide

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Chemical Name:N-[1-(1-(4-(imidazo(2,1-b)benzothiazol-2-yl)phenyl-1H-1,2,3-triazol-4-yl)-2-phenylethyl)]-2-[3,5-bis(trifluoromethyl)phenyl]acetamide
CAS No.:1388790-07-5
Molecular Formula:C₃₅H₂₄F₆N₆OS
Molecular Weight:690.672
Hs Code.:

Synonyms:N-[1-(1-(4-(imidazo(2,1-b)benzothiazol-2-yl)phenyl-1H-1,2,3-triazol-4-yl)-2-phenylethyl)]-2-[3,5-bis(trifluoromethyl)phenyl]acetamide

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Chemical Property of N-[1-(1-(4-(imidazo(2,1-b)benzothiazol-2-yl)phenyl-1H-1,2,3-triazol-4-yl)-2-phenylethyl)]-2-[3,5-bis(trifluoromethyl)phenyl]acetamide

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Technology Process of N-[1-(1-(4-(imidazo(2,1-b)benzothiazol-2-yl)phenyl-1H-1,2,3-triazol-4-yl)-2-phenylethyl)]-2-[3,5-bis(trifluoromethyl)phenyl]acetamide

There total 4 articles about N-[1-(1-(4-(imidazo(2,1-b)benzothiazol-2-yl)phenyl-1H-1,2,3-triazol-4-yl)-2-phenylethyl)]-2-[3,5-bis(trifluoromethyl)phenyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1388790-17-7
2-(4-azidophenyl)imidazo[2,1-b]benzothiazole

: 1388790-14-4
N-(1-phenylbut-3-yn-2-yl)-2-[3,5-bis(trifluoromethyl)phenyl]acetamide

: 1388790-07-5
N-[1-(1-(4-(imidazo(2,1-b)benzothiazol-2-yl)phenyl-1H-1,2,3-triazol-4-yl)-2-phenylethyl)]-2-[3,5-bis(trifluoromethyl)phenyl]acetamide

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In tetrahydrofuran; water; at 20 ℃; for 6h;
DOI:10.1016/j.bmcl.2012.05.078

Reference yield:

: N-(1-hydroxy-3-phenylpropan-2-yl)-2-[3,5-bis(trifluoromethyl)phenyl]acetamide

: 1388790-07-5
N-[1-(1-(4-(imidazo(2,1-b)benzothiazol-2-yl)phenyl-1H-1,2,3-triazol-4-yl)-2-phenylethyl)]-2-[3,5-bis(trifluoromethyl)phenyl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: Dess-Martin periodane / dichloromethane / 4 h / 20 °C / Inert atmosphere

2: potassium carbonate / methanol / 16 h / 0 - 20 °C

3: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tetrahydrofuran; water / 6 h / 20 °C

With copper(ll) sulfate pentahydrate; potassium carbonate; Dess-Martin periodane; sodium L-ascorbate; In tetrahydrofuran; methanol; dichloromethane; water; 1: Dess-Martin oxidation / 2: Bestmann-Ohira reaction / 3: Huisgen cycloaddition;
DOI:10.1016/j.bmcl.2012.05.078

Reference yield:

: N-(1-oxo-3-phenylpropan-2-yl)-2-[3,5-bis(trifluoromethyl)phenyl]acetamide

: 1388790-07-5
N-[1-(1-(4-(imidazo(2,1-b)benzothiazol-2-yl)phenyl-1H-1,2,3-triazol-4-yl)-2-phenylethyl)]-2-[3,5-bis(trifluoromethyl)phenyl]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / methanol / 16 h / 0 - 20 °C

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tetrahydrofuran; water / 6 h / 20 °C

With copper(ll) sulfate pentahydrate; potassium carbonate; sodium L-ascorbate; In tetrahydrofuran; methanol; water; 1: Bestmann-Ohira reaction / 2: Huisgen cycloaddition;
DOI:10.1016/j.bmcl.2012.05.078