3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl 4-methylpiperazine-1-carbodithioate

Base Information

Chemical Name:3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl 4-methylpiperazine-1-carbodithioate
CAS No.:1259017-50-9
Molecular Formula:C₃₁H₃₃ClFN₅O₃S₂
Molecular Weight:642.218
Hs Code.:

Synonyms:3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl 4-methylpiperazine-1-carbodithioate

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Chemical Property of 3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl 4-methylpiperazine-1-carbodithioate

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Technology Process of 3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl 4-methylpiperazine-1-carbodithioate

There total 8 articles about 3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl 4-methylpiperazine-1-carbodithioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 109-01-3
1-methyl-piperazine

: 75-15-0,12122-00-8
carbon disulfide

: 1259017-73-6
N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(3-chloropropoxy)-7-methoxyquina-zolin-4-amine

: 1259017-50-9
3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl 4-methylpiperazine-1-carbodithioate

Guidance literature:: 1-methyl-piperazine; With potassium phosphate; In N,N-dimethyl-formamide; for 0.25h;

carbon disulfide; In N,N-dimethyl-formamide; for 0.5h;

N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(3-chloropropoxy)-7-methoxyquina-zolin-4-amine; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.04.096

Reference yield:

: 692059-41-9
6-(3-chloropropoxy)-4-chloro-7-methoxyquinazoline

: 1259017-50-9
3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl 4-methylpiperazine-1-carbodithioate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / isopropyl alcohol / 3 h / Reflux

2.1: potassium phosphate / N,N-dimethyl-formamide / 0.25 h

2.2: 0.5 h

With potassium phosphate; triethylamine; In N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.bmcl.2011.04.096

Reference yield:

: 574738-93-5
6-(3-chloropropoxy)-7-methoxyquinazolin-4-ol

: 1259017-50-9
3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl 4-methylpiperazine-1-carbodithioate

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / 3 h / Reflux

2.1: triethylamine / isopropyl alcohol / 3 h / Reflux

3.1: potassium phosphate / N,N-dimethyl-formamide / 0.25 h

3.2: 0.5 h

With potassium phosphate; thionyl chloride; triethylamine; N,N-dimethyl-formamide; In N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.bmcl.2011.04.096