(+)-3-(1-nitrocyclohexyl) cycloheptanone

Base Information

• Chemical Name: (+)-3-(1-nitrocyclohexyl) cycloheptanone
• CAS No.: 160012-10-2
• Molecular Formula: C₁₃H₂₁NO₃
• Molecular Weight: 239.315
• Mol file: 160012-10-2.mol

Synonyms:(+)-3-(1-nitrocyclohexyl) cycloheptanone

Chemical Property of (+)-3-(1-nitrocyclohexyl) cycloheptanone

Chemical Property:

Purity/Quality:

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Technology Process of (+)-3-(1-nitrocyclohexyl) cycloheptanone

There total 2 articles about (+)-3-(1-nitrocyclohexyl) cycloheptanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

2-Cyclohepten-1-one (1121-66-0) + 1-nitrocyclohexane (1122-60-7) → (+)-3-(1-nitrocyclohexyl) cycloheptanone (160012-10-2)

Guidance literature:

With chloroform; 2,5-dimethyl-piperazine; trans-4,5-methano-L-proline; at 20 ℃; for 144h;

DOI:10.1021/ol0618407

Reference yield:

2-Cyclohepten-1-one (1121-66-0) + 1-nitrocyclohexane (1122-60-7) → (+)-3-(1-nitrocyclohexyl) cycloheptanone (160012-10-2) + 3-(1-nitrocyclohexyl)-cycloheptanone

Guidance literature:

With (L)-proline rubidium salt; In chloroform; for 20h; Yield given. Yields of byproduct given;

DOI:10.1016/0040-4039(94)88290-8

Reference yield:

(R,R)-2,3-butandiol (24347-58-8) + (+)-3-(1-nitrocyclohexyl) cycloheptanone (160012-10-2) → (2R,3R,7S)-2,3-Dimethyl-7-(1-nitro-cyclohexyl)-1,4-dioxa-spiro[4.6]undecane + (2R,3R,7R)-2,3-Dimethyl-7-(1-nitro-cyclohexyl)-1,4-dioxa-spiro[4.6]undecane

Guidance literature:

With toluene-4-sulfonic acid; In benzene; Title compound not separated from byproducts.; Heating;

DOI:10.1021/ol000170g

upstream raw materials:

2-Cyclohepten-1-one

1-nitrocyclohexane