3-(4-chlorobenzo[b]thiophen-2-yl)-5-(3 ,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole

Base Information

Chemical Name:3-(4-chlorobenzo[b]thiophen-2-yl)-5-(3 ,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole
CAS No.:1414379-44-4
Molecular Formula:C₁₈H₉Cl₃F₃NOS
Molecular Weight:450.696
Hs Code.:

Synonyms:3-(4-chlorobenzo[b]thiophen-2-yl)-5-(3 ,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole

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Chemical Property of 3-(4-chlorobenzo[b]thiophen-2-yl)-5-(3 ,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole

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Technology Process of 3-(4-chlorobenzo[b]thiophen-2-yl)-5-(3 ,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole

There total 7 articles about 3-(4-chlorobenzo[b]thiophen-2-yl)-5-(3 ,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1414379-27-3
1-(4-chlorobenzo[b]thiophen-2-yl)-3-(3 ,5-dichlorophenyl)-4,4,4-trifluorobut-2-en-1-one

: 1414379-44-4
3-(4-chlorobenzo[b]thiophen-2-yl)-5-(3 ,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole

Guidance literature:: With hydroxylamine hydrochloride; sodium hydroxide; In methanol; water; at 20 ℃; for 4h;

Reference yield:

: 66490-34-4
1-(4-chloro-1H-benzo[b]thiophen-2-yl)ethanone

: 1414379-44-4
3-(4-chlorobenzo[b]thiophen-2-yl)-5-(3 ,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -78 °C / Inert atmosphere

1.2: 2 h

2.1: thionyl chloride; pyridine / dichloromethane / 20 °C

3.1: hydroxylamine hydrochloride; sodium hydroxide / water; methanol / 4 h / 20 °C

With pyridine; thionyl chloride; hydroxylamine hydrochloride; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

: 1414379-09-1
1-(4-chlorobenzo[b]thiophen-2-yl)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxybutan-1-one

: 1414379-44-4
3-(4-chlorobenzo[b]thiophen-2-yl)-5-(3 ,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride; pyridine / dichloromethane / 20 °C

2: hydroxylamine hydrochloride; sodium hydroxide / water; methanol / 4 h / 20 °C

With pyridine; thionyl chloride; hydroxylamine hydrochloride; sodium hydroxide; In methanol; dichloromethane; water;